OBJECTIVE: To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. STUDY DESIGN: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). RESULTS: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. CONCLUSION: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
OBJECTIVE: To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. STUDY DESIGN: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). RESULTS: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. CONCLUSION: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
Authors: Bianca C Bianco; Fernanda M Scotti; Daniella S C Vieira; Michelle T Biz; Renata G Castro; Filipe Modolo Journal: Int J Exp Pathol Date: 2015-10-30 Impact factor: 1.925
Authors: Valéria Souza Freitas; Jean Nunes Dos Santos; Pedro Paulo de Andrade Santos; Cassiano Francisco Weege Nonaka; Leão Pereira Pinto; Lélia Batista de Souza Journal: Eur Arch Otorhinolaryngol Date: 2018-10-25 Impact factor: 2.503
Authors: Claudia M Gutschalk; Archana K Yanamandra; Nina Linde; Alice Meides; Sofia Depner; Margareta M Mueller Journal: Cancer Med Date: 2012-11-26 Impact factor: 4.452