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Literature DB >> 21255726

The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes.

Suzanne Hoppins¹, Frank Edlich, Megan M Cleland, Soojay Banerjee, J Michael McCaffery, Richard J Youle, Jodi Nunnari.

Abstract

In mammals, fusion of the mitochondrial outer membrane is controlled by two DRPs, MFN1 and MFN2, that function in place of a single outer membrane DRP, Fzo1 in yeast. We addressed the significance of two mammalian outer membrane fusion DRPs using an in vitro mammalian mitochondrial fusion assay. We demonstrate that heterotypic MFN1-MFN2 trans complexes possess greater efficacy in fusion as compared to homotypic MFN1 or MFN2 complexes. In addition, we show that the soluble form of the proapoptotic Bcl2 protein, Bax, positively regulates mitochondrial fusion exclusively through homotypic MFN2 trans complexes. Together, these data demonstrate functional and regulatory distinctions between MFN1 and MFN2 and provide insight into their unique physiological roles. Copyright Â

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Year: 2011 PMID： 21255726 PMCID： PMC3072068 DOI： 10.1016/j.molcel.2010.11.030

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

37 in total

1. Structure of Bax: coregulation of dimer formation and intracellular localization.

Authors: M Suzuki; R J Youle; N Tjandra
Journal: Cell Date: 2000-11-10 Impact factor: 41.582

2. Mitochondrial fusion intermediates revealed in vitro.

Authors: Shelly Meeusen; J Michael McCaffery; Jodi Nunnari
Journal: Science Date: 2004-08-05 Impact factor: 47.728

3. Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis.

Authors: Rie Sugioka; Shigeomi Shimizu; Yoshihide Tsujimoto
Journal: J Biol Chem Date: 2004-09-30 Impact factor: 5.157

4. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity.

Authors: Naotada Ishihara; Yuka Eura; Katsuyoshi Mihara
Journal: J Cell Sci Date: 2004-11-30 Impact factor: 5.285

5. Bcl-2 family interaction with the mitochondrial morphogenesis machinery.

Authors: M M Cleland; K L Norris; M Karbowski; C Wang; D-F Suen; S Jiao; N M George; X Luo; Z Li; R J Youle
Journal: Cell Death Differ Date: 2010-07-30 Impact factor: 15.828

6. Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization.

Authors: Margaret Neuspiel; Rodolfo Zunino; Sandhya Gangaraju; Peter Rippstein; Heidi McBride
Journal: J Biol Chem Date: 2005-05-04 Impact factor: 5.157

7. Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion.

Authors: Yuka Eura; Naotada Ishihara; Sadaki Yokota; Katsuyoshi Mihara
Journal: J Biochem Date: 2003-09 Impact factor: 3.387

8. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.

Authors: Ansgar Santel; Stephan Frank; Brigitte Gaume; Michael Herrler; Richard J Youle; Margaret T Fuller
Journal: J Cell Sci Date: 2003-05-20 Impact factor: 5.285

9. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.

Authors: Hsiuchen Chen; Scott A Detmer; Andrew J Ewald; Erik E Griffin; Scott E Fraser; David C Chan
Journal: J Cell Biol Date: 2003-01-13 Impact factor: 10.539

10. Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis.

Authors: Mariusz Karbowski; Damien Arnoult; Hsiuchen Chen; David C Chan; Carolyn L Smith; Richard J Youle
Journal: J Cell Biol Date: 2004-02-09 Impact factor: 10.539

105 in total

Review 1. Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.

Authors: Theodore J Wilson; Andrew M Slupe; Stefan Strack
Journal: Neurobiol Dis Date: 2012-01-24 Impact factor: 5.996

Review 2. Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion.

Authors: Kyriakos N Papanicolaou; Matthew M Phillippo; Kenneth Walsh
Journal: Am J Physiol Heart Circ Physiol Date: 2012-05-25 Impact factor: 4.733

Review 3. Mitochondrial dynamics as regulators of cancer biology.

Authors: Andrew Paul Trotta; Jerry Edward Chipuk
Journal: Cell Mol Life Sci Date: 2017-01-12 Impact factor: 9.261

4. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics.

Authors: Kevin B Clayton; Petar Podlesniy; Joana Figueiro-Silva; Guillermo López-Doménech; Lluis Benitez; Marta Enguita; Maria A Abad; Eduardo Soriano; Ramon Trullas
Journal: J Neurosci Date: 2012-01-25 Impact factor: 6.167

5. A catalytic domain variant of mitofusin requiring a wildtype paralog for function uncouples mitochondrial outer-membrane tethering and fusion.

Authors: Emily A Engelhart; Suzanne Hoppins
Journal: J Biol Chem Date: 2019-04-01 Impact factor: 5.157