Deborah J MacDonald1. 1. Division of Clinical Cancer Genetics, Department of Population Science, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. dmacdonald@coh.org
Abstract
OBJECTIVE: To provide an overview of hereditary cancer susceptibility genes and associated cancer risks. DATA SOURCES: Peer reviewed published research studies and review articles. CONCLUSIONS: Identifying deleterious mutations in cancer susceptibility genes allows for clarification of cancer risk in individual family members and risk-level appropriate screening, and risk management recommendations. Evolving knowledge of the role of germline mutations provides an unprecedented opportunity to reduce cancer incidence, morbidity, and morality. IMPLICATIONS FOR NURSING PRACTICE: To provide individuals/families with accurate cancer risk management information and guidance, oncology nurses must be familiar with scientific discoveries related to cancer susceptibility genes.
OBJECTIVE: To provide an overview of hereditary cancer susceptibility genes and associated cancer risks. DATA SOURCES: Peer reviewed published research studies and review articles. CONCLUSIONS: Identifying deleterious mutations in cancer susceptibility genes allows for clarification of cancer risk in individual family members and risk-level appropriate screening, and risk management recommendations. Evolving knowledge of the role of germline mutations provides an unprecedented opportunity to reduce cancer incidence, morbidity, and morality. IMPLICATIONS FOR NURSING PRACTICE: To provide individuals/families with accurate cancer risk management information and guidance, oncology nurses must be familiar with scientific discoveries related to cancer susceptibility genes.
Authors: Carmen Maria Dornelles Prolla; Patrícia Santos da Silva; Cristina Brinckmann Oliveira Netto; José Roberto Goldim; Patricia Ashton-Prolla Journal: Rev Lat Am Enfermagem Date: 2015 Jan-Feb