| Literature DB >> 2125529 |
Abstract
Programs directed towards the selection of etoposide and mitomycin C analogs which exhibit superior activity, reduced toxicity and improved pharmaceutics have met with partial success. Etopofos (BMY 40481) has been chosen for development as a prodrug of etoposide possessing superior pharmaceutical properties. BMY 25067, an analog of mitomycin C, is also under development based on its improved activity profile, acceptable toxicology profile and possibly different mechanism of action.Entities:
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Year: 1990 PMID： 2125529 DOI： 10.1016/0305-7372(90)90036-f
Source DB: PubMed Journal: Cancer Treat Rev ISSN： 0305-7372 Impact factor: 12.111