| Literature DB >> 21253000 |
César Nombela-Arrieta1, Jerome Ritz, Leslie E Silberstein.
Abstract
Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion. Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional roles in adult tissue homeostasis have remained enigmatic and are only just starting to be uncovered.Entities:
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Year: 2011 PMID: 21253000 PMCID: PMC3346289 DOI: 10.1038/nrm3049
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN: 1471-0072 Impact factor: 94.444