BACKGROUND: The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or pre eclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease, preterm birth, or small for gestational age (SGA). METHODS: Uric acid was measured in 1,541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and prepregnancy body mass index (BMI). RESULTS: First trimester uric acid in the highest quartile (>3.56 mg/dl) compared to lowest three quartiles was associated with an increased risk of developing pre-eclampsia (adjusted odds ratio (OR) = 1.82; 95% confidence interval (CI), 1.03-3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22-fold increased risk of hyperuricemic gestational hypertension (HU) and a 3.65-fold increased risk of hyperuricemic pre-eclampsia (HPU). High first trimester uric acid was not associated with gestational hypertension or pre-eclampsia without hyperuricemia (H or HP) at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r(2) = 0.23). CONCLUSIONS: First trimester elevated uric acid was associated with later pre-eclampsia and more strongly with pre-eclampsia and gestational hypertension with hyperuricemia.
BACKGROUND: The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or pre eclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease, preterm birth, or small for gestational age (SGA). METHODS:Uric acid was measured in 1,541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and prepregnancy body mass index (BMI). RESULTS: First trimester uric acid in the highest quartile (>3.56 mg/dl) compared to lowest three quartiles was associated with an increased risk of developing pre-eclampsia (adjusted odds ratio (OR) = 1.82; 95% confidence interval (CI), 1.03-3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22-fold increased risk of hyperuricemic gestational hypertension (HU) and a 3.65-fold increased risk of hyperuricemic pre-eclampsia (HPU). High first trimester uric acid was not associated with gestational hypertension or pre-eclampsia without hyperuricemia (H or HP) at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r(2) = 0.23). CONCLUSIONS: First trimester elevated uric acid was associated with later pre-eclampsia and more strongly with pre-eclampsia and gestational hypertension with hyperuricemia.
Authors: Richard J Johnson; Mark S Segal; Titte Srinivas; Ahsan Ejaz; Wei Mu; Carlos Roncal; Laura G Sánchez-Lozada; Michael Gersch; Bernardo Rodriguez-Iturbe; Duk-Hee Kang; Jaime Herrera Acosta Journal: J Am Soc Nephrol Date: 2005-04-20 Impact factor: 10.121
Authors: James M Roberts; Lisa M Bodnar; Kristine Y Lain; Carl A Hubel; Nina Markovic; Roberta B Ness; Robert W Powers Journal: Hypertension Date: 2005-10-24 Impact factor: 10.190
Authors: C L de Jong; K M Paarlberg; H P van Geijn; E J Schipper; A Bast; P J Kostense; G A Dekker Journal: J Perinat Med Date: 1997 Impact factor: 1.901
Authors: Richard J Johnson; Mehmet Kanbay; Duk-Hee Kang; Laura Gabriela Sánchez-Lozada; Daniel Feig Journal: Hypertension Date: 2011-08-29 Impact factor: 10.190
Authors: Florian G Scurt; Ronnie Morgenroth; Katrin Bose; Peter R Mertens; Christos Chatzikyrkou Journal: Geburtshilfe Frauenheilkd Date: 2022-03-03 Impact factor: 2.915
Authors: Che-Jung Chang; Dana Boyd Barr; P Barry Ryan; Parinya Panuwet; Melissa M Smarr; Ken Liu; Kurunthachalam Kannan; Volha Yakimavets; Youran Tan; ViLinh Ly; Carmen J Marsit; Dean P Jones; Elizabeth J Corwin; Anne L Dunlop; Donghai Liang Journal: Environ Int Date: 2021-11-01 Impact factor: 9.621