| Literature DB >> 21252630 |
Andrew P Steenhoff1, Joshua S Josephs, Richard M Rutstein, Kelly A Gebo, George K Siberry, Aditya H Gaur, Robert Warford, P Todd Korthuis, Stephen A Spector, Samir S Shah.
Abstract
The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4% of 23% (controls: 30%) and mean CD4 cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.Entities:
Mesh:
Year: 2011 PMID: 21252630 PMCID: PMC3576877 DOI: 10.1097/QAD.0b013e3283440583
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.177