Literature DB >> 21252223

The role of the human SWI5-MEI5 complex in homologous recombination repair.

Jingsong Yuan1, Junjie Chen.   

Abstract

The Swi5-Mei5 complex and its homologues are involved in specialized recombination pathways in budding and fission yeasts. Although the fission yeast homologue Swi5-Sfr1 is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromosomes. Here, we identify and characterize the human SWI5-MEI5 (C9orf119-C10orf78) complex. We showed that SWI5 and MEI5 form a stable complex in vitro and in vivo. The C-terminal Swi5 domain of SWI5 and the middle coiled-coil region of MEI5 dictate this conserved interaction. In addition, SWI5-MEI5 directly interacts with RAD51 in vitro. Depletion of SWI5 or MEI5 in human cells causes defects in homologous recombination repair. Finally, SWI5- or MEI5-depleted cells display enhanced sensitivity to ionizing radiation, consistent with the role of this complex in HR repair. Our results suggest that human SWI5-MEI5 has an evolutionarily conserved function in homologous recombination repair.

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Year:  2011        PMID： 21252223      PMCID： PMC3059048          DOI： 10.1074/jbc.M110.207290

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  32 in total

1.  Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

Authors:  Yufuko Akamatsu; Dorota Dziadkowiec; Mitsunori Ikeguchi; Hideo Shinagawa; Hiroshi Iwasaki
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-08       Impact factor: 11.205

Review 2.  Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

Authors:  Aziz Sancar; Laura A Lindsey-Boltz; Keziban Unsal-Kaçmaz; Stuart Linn
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

3.  Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.

Authors:  C Richardson; M E Moynahan; M Jasin
Journal:  Genes Dev       Date:  1998-12-15       Impact factor: 11.361

4.  Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3.

Authors:  A H McKee; N Kleckner
Journal:  Genetics       Date:  1997-07       Impact factor: 4.562

5.  DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA.

Authors:  P Sung; D L Robberson
Journal:  Cell       Date:  1995-08-11       Impact factor: 41.582

6.  Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs.

Authors:  M Takata; M S Sasaki; S Tachiiri; T Fukushima; E Sonoda; D Schild; L H Thompson; S Takeda
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

Review 7.  Emerging functions of BRCA2 in DNA recombination.

Authors:  Luca Pellegrini; Ashok Venkitaraman
Journal:  Trends Biochem Sci       Date:  2004-06       Impact factor: 13.807

8.  Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice.

Authors:  Bryan Deans; Carol S Griffin; Paul O'Regan; Maria Jasin; John Thacker
Journal:  Cancer Res       Date:  2003-12-01       Impact factor: 12.701

9.  Similarity of the yeast RAD51 filament to the bacterial RecA filament.

Authors:  T Ogawa; X Yu; A Shinohara; E H Egelman
Journal:  Science       Date:  1993-03-26       Impact factor: 47.728

10.  Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.

Authors:  Yufuko Akamatsu; Maria Jasin
Journal:  PLoS Genet       Date:  2010-10-14       Impact factor: 5.917
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  18 in total

Review 1.  DNA strand exchange and RecA homologs in meiosis.

Authors:  M Scott Brown; Douglas K Bishop
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-12-04       Impact factor: 10.005

Review 2.  An Overview of the Molecular Mechanisms of Recombinational DNA Repair.

Authors:  Stephen C Kowalczykowski
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-11-02       Impact factor: 10.005

3.  FIGNL1-containing protein complex is required for efficient homologous recombination repair.

Authors:  Jingsong Yuan; Junjie Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-10       Impact factor: 11.205

Review 4.  Homologous recombination and its regulation.

Authors:  Lumir Krejci; Veronika Altmannova; Mario Spirek; Xiaolan Zhao
Journal:  Nucleic Acids Res       Date:  2012-03-30       Impact factor: 16.971

5.  Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.

Authors:  Shang-Pu Tsai; Guan-Chin Su; Sheng-Wei Lin; Chan-I Chung; Xiaoyu Xue; Myun Hwa Dunlop; Yufuko Akamatsu; Maria Jasin; Patrick Sung; Peter Chi
Journal:  Nucleic Acids Res       Date:  2012-04-09       Impact factor: 16.971

6.  Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure.

Authors:  Yuichi Kokabu; Yasuto Murayama; Naoyuki Kuwabara; Tomotaka Oroguchi; Hiroshi Hashimoto; Yasuhiro Tsutsui; Naohito Nozaki; Satoko Akashi; Satoru Unzai; Toshiyuki Shimizu; Hiroshi Iwasaki; Mamoru Sato; Mitsunori Ikeguchi
Journal:  J Biol Chem       Date:  2011-10-27       Impact factor: 5.157

7.  The Swi2-Snf2-like protein Uls1 is involved in replication stress response.

Authors:  Magdalena Cal-Bakowska; Ireneusz Litwin; Tomasz Bocer; Robert Wysocki; Dorota Dziadkowiec
Journal:  Nucleic Acids Res       Date:  2011-07-15       Impact factor: 16.971

8.  Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex.

Authors:  Guan-Chin Su; Chan-I Chung; Chia-Yu Liao; Sheng-Wei Lin; Cheng-Ting Tsai; Tao Huang; Hung-Wen Li; Peter Chi
Journal:  Nucleic Acids Res       Date:  2013-09-27       Impact factor: 16.971

9.  DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.

Authors:  Yuxin Feng; David Singleton; Chun Guo; Amanda Gardner; Suresh Pakala; Rakesh Kumar; Elwood Jensen; Jinsong Zhang; Sohaib Khan
Journal:  PLoS One       Date:  2013-07-09       Impact factor: 3.240

10.  MEIOB targets single-strand DNA and is necessary for meiotic recombination.

Authors:  Benoit Souquet; Emilie Abby; Roxane Hervé; Friederike Finsterbusch; Sophie Tourpin; Ronan Le Bouffant; Clotilde Duquenne; Sébastien Messiaen; Emmanuelle Martini; Jacqueline Bernardino-Sgherri; Attila Toth; René Habert; Gabriel Livera
Journal:  PLoS Genet       Date:  2013-09-19       Impact factor: 5.917
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