BACKGROUND: Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls. METHODS: We measured anthropometrics, lung function, respiratory muscle force, handgrip (HG) force and fat free mass (FFM) at rest in 18 men with COPD (FEV(1)%=45±20) and 15 controls. We then performed a symptom limited cardiopulmonary exercise test (CPET) with similar load and used heart rate, and oxygen pulse (VO(2)/HR) to express cardiac function at rest and during exercise. We corrected the O(2) pulse by FFM. RESULTS: Patients and controls were similar in BMI and FFM. COPD patients had lower handgrip (37.8±7 vs. 55±2) kg. O(2) pulse and HG were associated (r=0.665). At rest, COPD patients had faster heart rate (76±11 vs. 61±5) and lower oxygen pulse. COPD patients had lower oxygen pulse mL/beat at exercise isotime (10.6±3.7 vs. 14.3±2.7), even adjusted by muscle mass. CONCLUSION: Handgrip is associated with impaired heart function at rest and during exercise in COPD patients even adjusting for muscle mass differences. Lower handgrip may be a marker of impaired cardiac function in COPD patients.
BACKGROUND: Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls. METHODS: We measured anthropometrics, lung function, respiratory muscle force, handgrip (HG) force and fat free mass (FFM) at rest in 18 men with COPD (FEV(1)%=45±20) and 15 controls. We then performed a symptom limited cardiopulmonary exercise test (CPET) with similar load and used heart rate, and oxygen pulse (VO(2)/HR) to express cardiac function at rest and during exercise. We corrected the O(2) pulse by FFM. RESULTS:Patients and controls were similar in BMI and FFM. COPDpatients had lower handgrip (37.8±7 vs. 55±2) kg. O(2) pulse and HG were associated (r=0.665). At rest, COPDpatients had faster heart rate (76±11 vs. 61±5) and lower oxygen pulse. COPDpatients had lower oxygen pulse mL/beat at exercise isotime (10.6±3.7 vs. 14.3±2.7), even adjusted by muscle mass. CONCLUSION: Handgrip is associated with impaired heart function at rest and during exercise in COPDpatients even adjusting for muscle mass differences. Lower handgrip may be a marker of impaired cardiac function in COPDpatients.
Authors: Rhoia Clara Neidenbach; Renate Oberhoffer; Lars Pieper; Sebastian Freilinger; Peter Ewert; Harald Kaemmerer; Nicole Nagdyman; Alfred Hager; Jan Müller Journal: Cardiovasc Diagn Ther Date: 2019-10
Authors: Siti Nur Baait Biniti Mohd Sokran; Vikram Mohan; Kamaria Kamaruddin; Mohd Daud Sulaiman; Yahya Awang; Ida Rosmini Binti Othman; Smiley Jesu Priya Victor Journal: Iran J Med Sci Date: 2015-07
Authors: Viktor Johansson Strandkvist; Helena Backman; Jenny Röding; Caroline Stridsman; Anne Lindberg Journal: Int J Chron Obstruct Pulmon Dis Date: 2016-10-07
Authors: Miroslav Kovarik; Vera Joskova; Anna Patkova; Vladimir Koblizek; Zdenek Zadak; Miloslav Hronek Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-12-01