Literature DB >> 21251194

Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of Syk.

T M Getz, A Mayanglambam, J L Daniel, S P Kunapuli.   

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Year:  2011        PMID： 21251194      PMCID： PMC3057064          DOI： 10.1111/j.1538-7836.2011.04192.x

Source DB:  PubMed          Journal:  J Thromb Haemost        ISSN： 1538-7836            Impact factor:   5.824


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  17 in total

1.  Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase.

Authors:  C Couture; S Williams; N Gauthier; P Tailor; T Mustelin
Journal:  Eur J Biochem       Date:  1997-06-01

2.  Protein kinase C[delta] differentially regulates platelet functional responses.

Authors:  Ramya Chari; Todd Getz; Bela Nagy; Kamala Bhavaraju; Yingying Mao; Yamini Saraswathy Bynagari; Swaminathan Murugappan; Keiko Nakayama; Satya P Kunapuli
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-02-12       Impact factor: 8.311

3.  syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction.

Authors:  O El-Hillal; T Kurosaki; H Yamamura; J P Kinet; A M Scharenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

4.  Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation.

Authors:  Laura Carsetti; Luca Laurenti; Stefania Gobessi; Pablo G Longo; Giuseppe Leone; Dimitar G Efremov
Journal:  Cell Signal       Date:  2009-03-16       Impact factor: 4.315

5.  Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

Authors:  G Martiny-Baron; M G Kazanietz; H Mischak; P M Blumberg; G Kochs; H Hug; D Marmé; C Schächtele
Journal:  J Biol Chem       Date:  1993-05-05       Impact factor: 5.157

6.  The spleen protein-tyrosine kinase TPK-IIB is highly similar to the catalytic domain of p72syk.

Authors:  A M Brunati; P James; B Guerra; M Ruzzene; A Donella-Deana; L A Pinna
Journal:  Eur J Biochem       Date:  1996-09-01

Review 7.  Isoform-specific functions of protein kinase C: the platelet paradigm.

Authors:  M T Harper; A W Poole
Journal:  Biochem Soc Trans       Date:  2007-11       Impact factor: 5.407

8.  Mechanism of activation and functional role of protein kinase Ceta in human platelets.

Authors:  Yamini S Bynagari; Bela Nagy; Florin Tuluc; Kamala Bhavaraju; Soochong Kim; K Vinod Vijayan; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2009-03-13       Impact factor: 5.157

9.  Differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets.

Authors:  Swaminathan Murugappan; Florin Tuluc; Robert T Dorsam; Haripriya Shankar; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2003-10-24       Impact factor: 5.157

10.  Impaired activation of platelets lacking protein kinase C-theta isoform.

Authors:  Bela Nagy; Kamala Bhavaraju; Todd Getz; Yamini S Bynagari; Soochong Kim; Satya P Kunapuli
Journal:  Blood       Date:  2009-01-22       Impact factor: 22.113
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  6 in total

1.  Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.

Authors:  Bhanu Kanth Manne; Rachit Badolia; Carol Dangelmaier; Johannes A Eble; Wilfried Ellmeier; Mark Kahn; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2015-03-12       Impact factor: 5.157

2.  Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets.

Authors:  Yamini S Bynagari-Settipalli; Parth Lakhani; Jianguo Jin; Kamala Bhavaraju; Mario C Rico; Soochong Kim; Donna Woulfe; Satya P Kunapuli
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-02-23       Impact factor: 8.311

3.  CGX1037 is a novel PKC isoform delta selective inhibitor in platelets.

Authors:  Dheeraj Bhavanasi; John C Kostyak; John Swindle; Laurie E Kilpatrick; Satya P Kunapuli
Journal:  Platelets       Date:  2014-01-16       Impact factor: 3.862

4.  The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner.

Authors:  D Vara; M Campanella; G Pula
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739

5.  Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).

Authors:  Bhanu Kanth Manne; Todd M Getz; Craig E Hughes; Osama Alshehri; Carol Dangelmaier; Ulhas P Naik; Steve P Watson; Satya P Kunapuli
Journal:  J Biol Chem       Date:  2013-01-22       Impact factor: 5.157

6.  Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+.

Authors:  Amanda J Unsworth; Holly Smith; Paul Gissen; Steve P Watson; Catherine J Pears
Journal:  J Biol Chem       Date:  2011-04-13       Impact factor: 5.157
  6 in total

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