Literature DB >> 21250968

Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.

Monika M Pichler, Claudia Bodner, Carina Fischer, Alexander J Deutsch, Karin Hiden, Christine Beham-Schmid, Werner Linkesch, Christian Guelly, Heinz Sill, Albert Wölfler.   

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Year:  2011        PMID： 21250968     DOI： 10.1111/j.1365-2141.2010.08404.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   8.615


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  3 in total

1.  Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.

Authors:  Isabella Fried; Claudia Bodner; Monika M Pichler; Karin Lind; Christine Beham-Schmid; Franz Quehenberger; Wolfgang R Sperr; Werner Linkesch; Heinz Sill; Albert Wölfler
Journal:  Haematologica       Date:  2011-10-11       Impact factor: 9.941

2.  Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.

Authors:  Joseph P Dexter; Patrick S Ward; Tathagata Dasgupta; Aaron M Hosios; Jeremy Gunawardena; Matthew G Vander Heiden
Journal:  J Biol Chem       Date:  2018-10-31       Impact factor: 5.157

3.  The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

Authors:  Patrick S Ward; Chao Lu; Justin R Cross; Omar Abdel-Wahab; Ross L Levine; Gary K Schwartz; Craig B Thompson
Journal:  J Biol Chem       Date:  2012-12-21       Impact factor: 5.486
  3 in total

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