Literature DB >> 21250818

Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives.

Vanessa Desplat1, Stéphane Moreau, Solene Belisle-Fabre, Denis Thiolat, Juliette Uranga, Romain Lucas, Laure de Moor, Stéphane Massip, Christian Jarry, Djavad M Mossalayi, Pascal Sonnet, Gérard Déléris, Jean Guillon.   

Abstract

A novel series of isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives was synthesized and evaluated in vitro against various human cancer cell lines for antiproliferative activity. These new compounds displayed activity against leukemia and breast cancer cell lines in the 3- to 18-µM concentration range.

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Year:  2011        PMID： 21250818     DOI： 10.3109/14756366.2010.548326

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  2 in total

1.  Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.

Authors:  Jean Guillon; Anita Cohen; Nassima Meriem Gueddouda; Rabindra Nath Das; Stéphane Moreau; Luisa Ronga; Solène Savrimoutou; Louise Basmaciyan; Alix Monnier; Myriam Monget; Sandra Rubio; Timothée Garnerin; Nadine Azas; Jean-Louis Mergny; Catherine Mullié; Pascal Sonnet
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

2.  Discovery of JAK2/3 Inhibitors from Quinoxalinone-Containing Compounds.

Authors:  Kamonpan Sanachai; Panupong Mahalapbutr; Lueacha Tabtimmai; Supaphorn Seetaha; Tanakorn Kittikool; Sirilata Yotphan; Kiattawee Choowongkomon; Thanyada Rungrotmongkol
Journal:  ACS Omega       Date:  2022-09-07
  2 in total

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