OBJECTIVE: This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk. METHODS: Eighty-one women aged 40-80 years with breast cancer and 81 controls of similar age were screened for metabolic syndrome prevalence and breast cancer risk factors, including age at diagnosis, age at menarche, reproductive status, live births, breastfeeding, family history of breast cancer, physical activity, cigarette smoking, body mass index, and metabolic syndrome parameters. Each variable was first assessed for baseline comparisons using the univariate model, and significant variables were then added to the multivariate conditional logistic regression model. RESULTS: Prevalence of metabolic syndrome was 59.2% in breast cancer patients, and 37% in the control group (p < 0.005). A positive and independent association was observed between metabolic syndrome and breast cancer risk (odds ratio = 2.49; 95% confidence interval 1.17-5.30). CONCLUSION: Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer.
OBJECTIVE: This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk. METHODS: Eighty-one women aged 40-80 years with breast cancer and 81 controls of similar age were screened for metabolic syndrome prevalence and breast cancer risk factors, including age at diagnosis, age at menarche, reproductive status, live births, breastfeeding, family history of breast cancer, physical activity, cigarette smoking, body mass index, and metabolic syndrome parameters. Each variable was first assessed for baseline comparisons using the univariate model, and significant variables were then added to the multivariate conditional logistic regression model. RESULTS: Prevalence of metabolic syndrome was 59.2% in breast cancerpatients, and 37% in the control group (p < 0.005). A positive and independent association was observed between metabolic syndrome and breast cancer risk (odds ratio = 2.49; 95% confidence interval 1.17-5.30). CONCLUSION:Metabolic syndrome is more prevalent in breast cancerpatients and is an independent risk factor for breast cancer.
Authors: Neil M Iyengar; Patrick G Morris; Xi Kathy Zhou; Ayca Gucalp; Dilip Giri; Michael D Harbus; Domenick J Falcone; Margaret D Krasne; Linda T Vahdat; Kotha Subbaramaiah; Monica Morrow; Clifford A Hudis; Andrew J Dannenberg Journal: Cancer Prev Res (Phila) Date: 2015-02-26
Authors: Jaclyn L F Bosco; Julie R Palmer; Deborah A Boggs; Elizabeth E Hatch; Lynn Rosenberg Journal: Breast Cancer Res Treat Date: 2012-06-19 Impact factor: 4.872
Authors: Christina M Dieli-Conwright; Kerry S Courneya; Wendy Demark-Wahnefried; Nathalie Sami; Kyuwan Lee; Thomas A Buchanan; Darcy V Spicer; Debu Tripathy; Leslie Bernstein; Joanne E Mortimer Journal: J Clin Oncol Date: 2018-01-22 Impact factor: 44.544