Literature DB >> 21249262

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates.

Riccardo Mossetti1, Diego Caprioglio, Giampiero Colombano, Gian Cesare Tron, Tracey Pirali.   

Abstract

α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are discussed.

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Year:  2011        PMID: 21249262     DOI: 10.1039/c0ob00979b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Pyridazine N-Oxides as Precursors to 2-Aminofurans: Scope and Limitations in Complexity Building Cascade Reactions.

Authors:  Maribel Borger; James H Frederich
Journal:  Org Lett       Date:  2019-03-22       Impact factor: 6.072

  1 in total

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