Gastric cancer in primary care: how hard should you look?

This article addresses the question of how vigorously a physician should search for gastric cancer among dyspeptic patients. To address this subject, two major questions are posed: Which patients presenting with dyspepsia are at highest risk of having gastric cancer? Does early diagnosis of symptomatic gastric cancer affect outcome? Although early detection of gastric cancer has been increasingly reported since the advent of fiberoptic endoscopy, factors such as lead time bias and an unchanged case-fatality rate preclude a definitive conclusion of improved treatment outcomes resulting from early detection. At present, a policy of routine immediate investigation of dyspeptic patients has not been shown to reduce gastric cancer mortality.