James T Broome1, Carmen C Solorzano. 1. Division of Surgical Oncology and Endocrine Surgery, Department of Surgical Sciences, Vanderbilt University, Nashville, Tennessee 37232-6860, USA. james.broome@vanderbilt.edu
Abstract
OBJECTIVE: To review suspected causes of lithium-induced hyperparathyroidism, disease presentation, underlying pathology, and current recommendations and trends in medical and surgical treatment. METHODS: Relevant literature was reviewed. RESULTS: Lithium carbonate therapy has continued to be a mainstay of treatment for bipolar disease and schizoaffective disorder since its introduction into clinical use. Several metabolic consequences are associated with its long-term use, including hypercalcemia and hyperparathyroidism. CONCLUSIONS: Until further data become available, the surgeon should remain vigilant for the presence of pathologically active glands that may manifest their function at different times during the disease course.
OBJECTIVE: To review suspected causes of lithium-induced hyperparathyroidism, disease presentation, underlying pathology, and current recommendations and trends in medical and surgical treatment. METHODS: Relevant literature was reviewed. RESULTS:Lithium carbonate therapy has continued to be a mainstay of treatment for bipolar disease and schizoaffective disorder since its introduction into clinical use. Several metabolic consequences are associated with its long-term use, including hypercalcemia and hyperparathyroidism. CONCLUSIONS: Until further data become available, the surgeon should remain vigilant for the presence of pathologically active glands that may manifest their function at different times during the disease course.
Authors: Felix Haglund; Ming Lu; Vladana Vukojević; Inga-Lena Nilsson; Adam Andreasson; Mensur Džabić; Robert Bränström; Anders Höög; C Christofer Juhlin; Catharina Larsson Journal: PLoS One Date: 2012-05-11 Impact factor: 3.240