OBJECTIVE: To understand the role of leptin and adiponectin in obese asthmatics. METHODS: We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects. RESULTS: We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11). CONCLUSION: Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
OBJECTIVE: To understand the role of leptin and adiponectin in obese asthmatics. METHODS: We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects. RESULTS: We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11). CONCLUSION: Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
Authors: Njira L Lugogo; John W Hollingsworth; Druhan L Howell; Loretta G Que; Dave Francisco; Tony D Church; Erin N Potts-Kant; Jennifer L Ingram; Ying Wang; Sin-Ho Jung; Monica Kraft Journal: Am J Respir Crit Care Med Date: 2012-07-05 Impact factor: 21.405
Authors: Schuyler J Halverson; Tracy Warhoover; Gregory A Mencio; Steven A Lovejoy; Jeffrey E Martus; Jonathan G Schoenecker Journal: J Bone Joint Surg Am Date: 2017-05-17 Impact factor: 5.284
Authors: Juanita H J Vernooy; Niki D J Ubags; Guy G Brusselle; Jan Tavernier; Benjamin T Suratt; Guy F Joos; Emiel F M Wouters; Ken R Bracke Journal: Pulm Pharmacol Ther Date: 2013-03-27 Impact factor: 3.410