OBJECTIVES: Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN). METHODS: Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotional judgement and passive picture viewing in 25 patients with MDD and 25 healthy controls in an event-related fMRI design. RESULTS: Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. Unlike in healthy subjects, the anterior medial cortical NBRs were no longer parametrically modulated by the degree of self-relatedness in MDD patients. CONCLUSIONS: Our findings suggest that reduced NBRs in the anterior regions of the default-mode network may signify decoupling from self-relatedness in MDD patients with the consecutive abnormal increase of self-focus.
OBJECTIVES: Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN). METHODS: Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotional judgement and passive picture viewing in 25 patients with MDD and 25 healthy controls in an event-related fMRI design. RESULTS: Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. Neuroimaging results in MDDpatients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. Unlike in healthy subjects, the anterior medial cortical NBRs were no longer parametrically modulated by the degree of self-relatedness in MDDpatients. CONCLUSIONS: Our findings suggest that reduced NBRs in the anterior regions of the default-mode network may signify decoupling from self-relatedness in MDDpatients with the consecutive abnormal increase of self-focus.
Authors: Meneka K Sidhu; Pamela J Thompson; Britta Wandschneider; Alexandra Foulkes; Jane de Tisi; Jason Stretton; Marina Perona; Maria Thom; Silvia B Bonelli; Jane Burdett; Elaine Williams; John S Duncan; Mar Matarin Journal: CNS Neurosci Ther Date: 2018-06-27 Impact factor: 5.243
Authors: Oliver G Bosch; Julia S Rihm; Milan Scheidegger; Hans-Peter Landolt; Philipp Stämpfli; Janis Brakowski; Fabrizio Esposito; Björn Rasch; Erich Seifritz Journal: Proc Natl Acad Sci U S A Date: 2013-11-11 Impact factor: 11.205
Authors: Tiffany C Ho; Colm G Connolly; Eva Henje Blom; Kaja Z LeWinn; Irina A Strigo; Martin P Paulus; Guido Frank; Jeffrey E Max; Jing Wu; Melanie Chan; Susan F Tapert; Alan N Simmons; Tony T Yang Journal: Biol Psychiatry Date: 2014-09-16 Impact factor: 13.382
Authors: Judith K Morgan; Marigrace Ambrosia; Erika E Forbes; Jill M Cyranowski; Marlissa C Amole; Jennifer S Silk; Rosalind D Elliott; Holly A Swartz Journal: J Affect Disord Date: 2015-08-24 Impact factor: 4.839