Literature DB >> 21246421

Embryonic stem cells: are useful in clinic treatments?

Justo Aznar1, Jose Luis Sánchez.   

Abstract

It is not uncommon to find statements in the social media and even in some scientific journals declaring that embryonic stem cells can be used in human medicine for therapeutic purposes. In our opinion, this statement does not fit the medical reality. To go into this subject in depth, and if possible to clarify it, we reviewed the most recent literature on clinical trials conducted with embryonic stem cells, concluding that up to the present time, there is only one ongoing clinical trial being carried out with these types of cells to treat a small group of patients with spinal cord injury. The results of this trial have still not been published. In conclusion, at present, there is only evidence of one phase I clinical trial conducted with embryonic stem cells, in comparison to the numerous trials conducted with adult stem cells.

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Year:  2011        PMID: 21246421     DOI: 10.1007/s13105-010-0064-0

Source DB:  PubMed          Journal:  J Physiol Biochem        ISSN: 1138-7548            Impact factor:   4.158


  9 in total

1.  Biomedicine. Selling the stem cell dream.

Authors:  Martin Enserink
Journal:  Science       Date:  2006-07-14       Impact factor: 47.728

2.  Treating diseases with adult stem cells.

Authors:  David A Prentice; Gene Tarne
Journal:  Science       Date:  2007-01-19       Impact factor: 47.728

3.  FDA scrutinizes human stem cell therapies.

Authors:  Jeffrey L Fox
Journal:  Nat Biotechnol       Date:  2008-06       Impact factor: 54.908

4.  Geron gets green light for human trial of ES cell-derived product.

Authors:  Joe Alper
Journal:  Nat Biotechnol       Date:  2009-03       Impact factor: 54.908

Review 5.  Derive and conquer: sourcing and differentiating stem cells for therapeutic applications.

Authors:  Irina Klimanskaya; Nadia Rosenthal; Robert Lanza
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

6.  Therapeutic cloning in individual parkinsonian mice.

Authors:  Viviane Tabar; Mark Tomishima; Georgia Panagiotakos; Sayaka Wakayama; Jayanthi Menon; Bill Chan; Eiji Mizutani; George Al-Shamy; Hiroshi Ohta; Teruhiko Wakayama; Lorenz Studer
Journal:  Nat Med       Date:  2008-03-23       Impact factor: 53.440

Review 7.  Tolerance strategies for stem-cell-based therapies.

Authors:  Ann P Chidgey; Daniel Layton; Alan Trounson; Richard L Boyd
Journal:  Nature       Date:  2008-05-15       Impact factor: 49.962

Review 8.  Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases.

Authors:  Richard K Burt; Yvonne Loh; William Pearce; Nirat Beohar; Walter G Barr; Robert Craig; Yanting Wen; Jonathan A Rapp; John Kessler
Journal:  JAMA       Date:  2008-02-27       Impact factor: 56.272

9.  Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient.

Authors:  Ninette Amariglio; Abraham Hirshberg; Bernd W Scheithauer; Yoram Cohen; Ron Loewenthal; Luba Trakhtenbrot; Nurit Paz; Maya Koren-Michowitz; Dalia Waldman; Leonor Leider-Trejo; Amos Toren; Shlomi Constantini; Gideon Rechavi
Journal:  PLoS Med       Date:  2009-02-17       Impact factor: 11.069

  9 in total
  7 in total

1.  Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes.

Authors:  Yogish C Kudva; Seiga Ohmine; Lucas V Greder; James R Dutton; Adam Armstrong; Josep Genebriera De Lamo; Yulia Krotova Khan; Tayaramma Thatava; Mamoru Hasegawa; Noemi Fusaki; Jonathan M W Slack; Yasuhiro Ikeda
Journal:  Stem Cells Transl Med       Date:  2012-05-30       Impact factor: 6.940

2.  Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells.

Authors:  Seiga Ohmine; Allan B Dietz; Michael C Deeds; Katherine A Hartjes; David R Miller; Tayaramma Thatava; Toshie Sakuma; Yogish C Kudva; Yasuhiro Ikeda
Journal:  Stem Cell Res Ther       Date:  2011-11-16       Impact factor: 6.832

3.  Generation and applications of human pluripotent stem cells induced into neural lineages and neural tissues.

Authors:  Y Martinez; M Dubois-Dauphin; K-H Krause
Journal:  Front Physiol       Date:  2012-03-19       Impact factor: 4.566

4.  Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats.

Authors:  Sining Feng; Shuai Wang; Shi Sun; Hao Su; Lixin Zhang
Journal:  Mol Med Rep       Date:  2021-03-02       Impact factor: 2.952

Review 5.  Cell transplantation for spinal cord injury: a systematic review.

Authors:  Jun Li; Guilherme Lepski
Journal:  Biomed Res Int       Date:  2013-01-15       Impact factor: 3.411

Review 6.  Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions.

Authors:  Vikram Sabapathy; George Tharion; Sanjay Kumar
Journal:  Stem Cells Int       Date:  2015-07-09       Impact factor: 5.443

Review 7.  Perspectives on the use of stem cells for autism treatment.

Authors:  Dario Siniscalco; James Jeffrey Bradstreet; Nataliia Sych; Nicola Antonucci
Journal:  Stem Cells Int       Date:  2013-10-10       Impact factor: 5.443

  7 in total

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