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Literature DB >> 21246224

Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

Christian Blahak¹, Hans-Holger Capelle, Hansjoerg Baezner, Thomas M Kinfe, Michael G Hennerici, Joachim K Krauss.

Abstract

Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.

Entities: Chemical Disease Species

Mesh：

Year: 2011 PMID： 21246224 DOI： 10.1007/s00702-010-0544-y

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

25 in total

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7. Efficient internal pallidal stimulation in Gilles de la Tourette syndrome: a case report.

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9. Health-related quality of life in segmental dystonia is improved by bilateral pallidal stimulation.

Authors: C Blahak; J C Wöhrle; H H Capelle; H Bäzner; E Grips; R Weigel; K Kekelia; J K Krauss
Journal: J Neurol Date: 2008-01-23 Impact factor: 4.849

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Authors: Jill L Ostrem; William J Marks; Monica M Volz; Susan L Heath; Philip A Starr
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2. Permanent isolated micrographia from traumatic basal ganglia injury.

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Review 4. Deep brain stimulation for movement disorders: update on recent discoveries and outlook on future developments.

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Journal: J Neural Transm (Vienna) Date: 2014-08-01 Impact factor: 3.575