Literature DB >> 21245272

Staphylococcal alpha-toxin is a strong inducer of interleukin-17 in humans.

Margarete Niebuhr1, Merle Gathmann, Helena Scharonow, Diana Mamerow, Susanne Mommert, Hari Balaji, Thomas Werfel.   

Abstract

Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus, with one-third of isolates producing alpha-toxin. Moreover, S. aureus colonization is positively correlated with the severity of eczema. Interleukin-17A (IL-17A) has gained attention in diseases associated with chronic skin infections. The aim of this study was to investigate the effects of sublytic alpha-toxin concentrations on IL-17A production. Sublytic alpha-toxin concentrations strongly induced IL-17A in peripheral blood mononuclear cells (PBMCs), isolated CD4(+) T cells, polarized Th17 cells, and Th17 clones from reactive atopy patch test lesions and blood from AD patients. Alpha-toxin induced IL-17A directly in T cells. The effect of alpha-toxin was further amplified by upregulation of IL-1 in monocytes. In conclusion, higher levels of IL-17A secretion induced by alpha-toxin in the skin partially explain how colonization with S. aureus can contribute to chronic skin inflammation.

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Year:  2011        PMID： 21245272      PMCID： PMC3067557          DOI： 10.1128/IAI.00958-10

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  44 in total

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  33 in total

1.  The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300.

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Authors:  Santiago M Lattar; Mariángeles Noto Llana; Philippe Denoël; Sophie Germain; Fernanda R Buzzola; Jean C Lee; Daniel O Sordelli
Journal:  Infect Immun       Date:  2013-10-14       Impact factor: 3.441

4.  Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.

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Journal:  Infect Immun       Date:  2012-06-25       Impact factor: 3.441

Review 5.  The influence of skin microorganisms on cutaneous immunity.

Authors:  Yasmine Belkaid; Samira Tamoutounour
Journal:  Nat Rev Immunol       Date:  2016-05-27       Impact factor: 53.106

6.  Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study.

Authors:  M Ahmed Ali; E S Mikhael; A Abdelkader; L Mansour; R El Essawy; R El Sayed; A Eladawy; A Mukhtar
Journal:  Eur J Trauma Emerg Surg       Date:  2017-09-15       Impact factor: 3.693

7.  Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.

Authors:  Peter A Szabo; Ankur Goswami; Delfina M Mazzuca; Kyoungok Kim; David B O'Gorman; David A Hess; Ian D Welch; Howard A Young; Bhagirath Singh; John K McCormick; S M Mansour Haeryfar
Journal:  J Immunol       Date:  2017-02-20       Impact factor: 5.422

Review 8.  Immunopathogenesis of Staphylococcus aureus pulmonary infection.

Authors:  Dane Parker; Alice Prince
Journal:  Semin Immunopathol       Date:  2011-10-31       Impact factor: 9.623

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Authors:  Allyson L Byrd; Yasmine Belkaid; Julia A Segre
Journal:  Nat Rev Microbiol       Date:  2018-01-15       Impact factor: 60.633

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Authors:  A Heratizadeh; T Werfel; L M Rösner
Journal:  Hautarzt       Date:  2015-02       Impact factor: 0.751
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