Literature DB >> 21245141

Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation.

Sarit Mizrachy-Schwartz1, Noam Cohen, Shoshana Klein, Nataly Kravchenko-Balasha, Alexander Levitzki.   

Abstract

We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.

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Year:  2011        PMID： 21245141      PMCID： PMC3083231          DOI： 10.1074/jbc.M110.211813

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  42 in total

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Journal:  Curr Biol       Date:  1998 Dec 17-31       Impact factor: 10.834

4.  Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.

Authors:  A G Kayali; J Eichhorn; T Haruta; A J Morris; J G Nelson; P Vollenweider; J M Olefsky; N J Webster
Journal:  J Biol Chem       Date:  1998-05-29       Impact factor: 5.157

5.  C-Myc 5' untranslated region contains an internal ribosome entry segment.

Authors:  M Stoneley; F E Paulin; J P Le Quesne; S A Chappell; A E Willis
Journal:  Oncogene       Date:  1998-01-22       Impact factor: 9.867

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Journal:  Clin Cancer Res       Date:  1999-08       Impact factor: 12.531

7.  PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

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Journal:  Cell       Date:  1991-05-03       Impact factor: 41.582

8.  Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies.

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Journal:  Anal Biochem       Date:  1996-05-01       Impact factor: 3.365

Review 9.  Tumor suppressors and cell metabolism: a recipe for cancer growth.

Authors:  Russell G Jones; Craig B Thompson
Journal:  Genes Dev       Date:  2009-03-01       Impact factor: 11.361

10.  Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

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Journal:  J Biol Chem       Date:  1996-01-12       Impact factor: 5.157
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  19 in total

Review 1.  Epithelial cell polarity, stem cells and cancer.

Authors:  Fernando Martin-Belmonte; Mirna Perez-Moreno
Journal:  Nat Rev Cancer       Date:  2011-12-15       Impact factor: 60.716

2.  Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Authors:  Gulsum E Muku; Nicholas Blazanin; Fangcong Dong; Philip B Smith; Diane Thiboutot; Krishne Gowda; Shantu Amin; Iain A Murray; Gary H Perdew
Journal:  Toxicol Sci       Date:  2019-06-21       Impact factor: 4.849

3.  Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.

Authors:  S Zhang; Q Qi; C B Chan; W Zhou; J Chen; H R Luo; C Appin; D J Brat; K Ye
Journal:  Cell Death Differ       Date:  2015-05-22       Impact factor: 15.828

4.  Therapeutic destruction of insulin receptor substrates for cancer treatment.

Authors:  Hadas Reuveni; Efrat Flashner-Abramson; Lilach Steiner; Kirill Makedonski; Renduo Song; Alexei Shir; Meenhard Herlyn; Menashe Bar-Eli; Alexander Levitzki
Journal:  Cancer Res       Date:  2013-05-07       Impact factor: 12.701

5.  Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.

Authors:  Karin Bartel; Rolf Müller; Karin von Schwarzenberg
Journal:  J Biol Chem       Date:  2019-10-11       Impact factor: 5.157

6.  Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression.

Authors:  Xiu Mei Ma; Zhi Hua Shen; Zhi Yao Liu; Fang Wang; Ling Hai; Lin Tao Gao; Hai Sheng Wang
Journal:  Int J Clin Exp Pathol       Date:  2014-08-15

Review 7.  AMPK as a potential anticancer target - friend or foe?

Authors:  Hsiao-Ching Chuang; Chih-Chien Chou; Samuel K Kulp; Ching-Shih Chen
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

8.  GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy.

Authors:  Mihwa Kim; Ji-Yeon Jung; Seungho Choi; Hyunseung Lee; Liza D Morales; Jeong-Tae Koh; Sun Hun Kim; Yoo-Duk Choi; Chan Choi; Thomas J Slaga; Won Jae Kim; Dae Joon Kim
Journal:  Autophagy       Date:  2016-10-18       Impact factor: 16.016

9.  Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart.

Authors:  Ji Li; Dake Qi; Haiying Cheng; Xiaoyue Hu; Edward J Miller; Xiaohong Wu; Kerry S Russell; Nicole Mikush; Jiasheng Zhang; Lei Xiao; Robert S Sherwin; Lawrence H Young
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

10.  Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

Authors:  Xiaona Liu; Rishi Raj Chhipa; Shabnam Pooya; Matthew Wortman; Sara Yachyshin; Lionel M L Chow; Ashish Kumar; Xuan Zhou; Ying Sun; Brian Quinn; Christopher McPherson; Ronald E Warnick; Ady Kendler; Shailendra Giri; Jeroen Poels; Koenraad Norga; Benoit Viollet; Gregory A Grabowski; Biplab Dasgupta
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205
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