Literature DB >> 21245058

Genome-wide association studies of atrial fibrillation: past, present, and future.

Moritz F Sinner1, Patrick T Ellinor, Thomas Meitinger, Emelia J Benjamin, Stefan Kääb.   

Abstract

Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF.

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Year:  2011        PMID： 21245058      PMCID： PMC3039249          DOI： 10.1093/cvr/cvr001

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  75 in total

1.  A mutation in the RIEG1 gene associated with Peters' anomaly.

Authors:  W Doward; R Perveen; I C Lloyd; A E Ridgway; L Wilson; G C Black
Journal:  J Med Genet       Date:  1999-02       Impact factor: 6.318

Review 2.  Genome-wide association studies for common diseases and complex traits.

Authors:  Joel N Hirschhorn; Mark J Daly
Journal:  Nat Rev Genet       Date:  2005-02       Impact factor: 53.242

3.  A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

Authors:  Dan E Arking; Arne Pfeufer; Wendy Post; W H Linda Kao; Christopher Newton-Cheh; Morna Ikeda; Kristen West; Carl Kashuk; Mahmut Akyol; Siegfried Perz; Shapour Jalilzadeh; Thomas Illig; Christian Gieger; Chao-Yu Guo; Martin G Larson; H Erich Wichmann; Eduardo Marbán; Christopher J O'Donnell; Joel N Hirschhorn; Stefan Kääb; Peter M Spooner; Thomas Meitinger; Aravinda Chakravarti
Journal:  Nat Genet       Date:  2006-04-30       Impact factor: 38.330

4.  Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.

Authors:  M E Piedra; J M Icardo; M Albajar; J C Rodriguez-Rey; M A Ros
Journal:  Cell       Date:  1998-08-07       Impact factor: 41.582

5.  The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals.

Authors:  M Logan; S M Pagán-Westphal; D M Smith; L Paganessi; C J Tabin
Journal:  Cell       Date:  1998-08-07       Impact factor: 41.582

6.  Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation.

Authors:  Cha-Gyun Jung; Hye-Jung Kim; Makoto Kawaguchi; Kum Kum Khanna; Hideki Hida; Kiyofumi Asai; Hitoo Nishino; Yutaka Miura
Journal:  Development       Date:  2005-10-26       Impact factor: 6.868

7.  Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.

Authors:  Dipika Tuteja; Danyan Xu; Valeriy Timofeyev; Ling Lu; Dipika Sharma; Zhao Zhang; Yanfang Xu; Liping Nie; Ana E Vázquez; J Nilas Young; Kathryn A Glatter; Nipavan Chiamvimonvat
Journal:  Am J Physiol Heart Circ Physiol       Date:  2005-07-29       Impact factor: 4.733

8.  Familial aggregation of atrial fibrillation in Iceland.

Authors:  David O Arnar; Sverrir Thorvaldsson; Teri A Manolio; Gudmundur Thorgeirsson; Kristleifur Kristjansson; Hakon Hakonarson; Kari Stefansson
Journal:  Eur Heart J       Date:  2006-01-20       Impact factor: 29.983

9.  Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.

Authors:  M Haïssaguerre; P Jaïs; D C Shah; A Takahashi; M Hocini; G Quiniou; S Garrigue; A Le Mouroux; P Le Métayer; J Clémenty
Journal:  N Engl J Med       Date:  1998-09-03       Impact factor: 91.245

10.  Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.

Authors:  Xiaodong Sun; Henry F Frierson; Ceshi Chen; Changling Li; Qimei Ran; Kristen B Otto; Brandi L Cantarel; Brandi M Cantarel; Robert L Vessella; Allen C Gao; John Petros; Yutaka Miura; Jonathan W Simons; Jin-Tang Dong
Journal:  Nat Genet       Date:  2005-03-06       Impact factor: 38.330
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  31 in total

1.  Weighted gene coexpression network analysis of human left atrial tissue identifies gene modules associated with atrial fibrillation.

Authors:  Nicholas Tan; Mina K Chung; Jonathan D Smith; Jeffrey Hsu; David Serre; David W Newton; Laurie Castel; Edward Soltesz; Gosta Pettersson; A Marc Gillinov; David R Van Wagoner; John Barnard
Journal:  Circ Cardiovasc Genet       Date:  2013-07-17

Review 2.  Common variants for atrial fibrillation: results from genome-wide association studies.

Authors:  Xinyuan Liu; Fei Wang; Ashley C Knight; Jiangmin Zhao; Junjie Xiao
Journal:  Hum Genet       Date:  2011-07-07       Impact factor: 4.132

Review 3.  Atrial fibrillation and heart failure: cause or effect?

Authors:  Christina Luong; Marion E Barnes; Teresa S M Tsang
Journal:  Curr Heart Fail Rep       Date:  2014-12

4.  Computational simulations of the effects of the G229D KCNQ1 mutation on human atrial fibrillation.

Authors:  Indana Zulfa; Eun Bo Shim; Kwang-Soup Song; Ki Moo Lim
Journal:  J Physiol Sci       Date:  2016-02-27       Impact factor: 2.781

5.  [Molecular mechanisms of atrial fibrillation: potential role of microRNAs as new therapeutic targets and potential biomarkers].

Authors:  R Wakili; S Clauß; S Kääb
Journal:  Herz       Date:  2012-03       Impact factor: 1.443

Review 6.  Translational research in atrial fibrillation: a quest for mechanistically based diagnosis and therapy.

Authors:  Felipe Atienza; Raphael P Martins; José Jalife
Journal:  Circ Arrhythm Electrophysiol       Date:  2012-09-27

Review 7.  Global epidemiology of atrial fibrillation.

Authors:  Faisal Rahman; Gene F Kwan; Emelia J Benjamin
Journal:  Nat Rev Cardiol       Date:  2014-08-12       Impact factor: 32.419

8.  Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

Authors:  Xiao-Dong Zhang; Valeriy Timofeyev; Ning Li; Richard E Myers; Dai-Min Zhang; Anil Singapuri; Victor C Lau; Chris T Bond; John Adelman; Deborah K Lieu; Nipavan Chiamvimonvat
Journal:  Cardiovasc Res       Date:  2013-11-26       Impact factor: 10.787

9.  Atrial Fibrillation and SCN5A Variants.

Authors:  Eleonora Savio-Galimberti; Dawood Darbar
Journal:  Card Electrophysiol Clin       Date:  2014-12-01

10.  Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study.

Authors:  Honghuang Lin; Moritz F Sinner; Jennifer A Brody; Dan E Arking; Kathryn L Lunetta; Michiel Rienstra; Steven A Lubitz; Jared W Magnani; Nona Sotoodehnia; Barbara McKnight; David D McManus; Eric Boerwinkle; Bruce M Psaty; Jerome I Rotter; Joshua C Bis; Richard A Gibbs; Donna Muzny; Christie L Kovar; Alanna C Morrison; Mayetri Gupta; Aaron R Folsom; Stefan Kääb; Susan R Heckbert; Alvaro Alonso; Patrick T Ellinor; Emelia J Benjamin
Journal:  Heart Rhythm       Date:  2013-11-14       Impact factor: 6.343
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