OBJECTIVE: The aim of this neuropathological study was to determine the prevalence of the different cerebrovascular lesions to be attributed to cerebral amyloid angiopathy (CAA) and of those associated with the severity of the Alzheimer dementia (AD) itself. PATIENTS AND METHODS: The cerebrovascular lesions were compared separately in 40 brains of patients with mild and 50 with severe AD features. In the two groups, the number of lesions were compared between the brains with severe and those with mild of absent CAA. RESULTS: The age of the patients, the vascular risk factors and antithrombotic treatment were similar in all the compared groups. The brains with mild and severe AD features and with CAA contained more haematomas, cortical micro-infarcts and micro-bleeds, and more severe white matter changes, and cortico-subcortical and white matter mini-bleeds. In the CAA brains with severe AD features, also more cortical territorial infarcts were observed, compared to those with mild AD features. CONCLUSIONS: The increase in cortical infarcts cannot be attributed to the CAA alone, but also to the severity of the degenerative features, implying additional vascular factors in the pathogenesis of AD.
OBJECTIVE: The aim of this neuropathological study was to determine the prevalence of the different cerebrovascular lesions to be attributed to cerebral amyloid angiopathy (CAA) and of those associated with the severity of the Alzheimer dementia (AD) itself. PATIENTS AND METHODS: The cerebrovascular lesions were compared separately in 40 brains of patients with mild and 50 with severe AD features. In the two groups, the number of lesions were compared between the brains with severe and those with mild of absent CAA. RESULTS: The age of the patients, the vascular risk factors and antithrombotic treatment were similar in all the compared groups. The brains with mild and severe AD features and with CAA contained more haematomas, cortical micro-infarcts and micro-bleeds, and more severe white matter changes, and cortico-subcortical and white matter mini-bleeds. In the CAA brains with severe AD features, also more cortical territorial infarcts were observed, compared to those with mild AD features. CONCLUSIONS: The increase in cortical infarcts cannot be attributed to the CAA alone, but also to the severity of the degenerative features, implying additional vascular factors in the pathogenesis of AD.
Authors: Maya Koronyo-Hamaoui; Kandarp Shah; Yosef Koronyo; Ellen Bernstein; Jorge F Giani; Tea Janjulia; Keith L Black; Peng D Shi; Romer A Gonzalez-Villalobos; Sebastien Fuchs; Xiao Z Shen; Kenneth E Bernstein Journal: Curr Hypertens Rep Date: 2014-07 Impact factor: 5.369
Authors: Irene B Meier; Yian Gu; Vanessa A Guzaman; Anne F Wiegman; Nicole Schupf; Jennifer J Manly; José A Luchsinger; Anand Viswanathan; Sergi Martinez-Ramirez; Steven M Greenberg; Richard Mayeux; Adam M Brickman Journal: Cerebrovasc Dis Date: 2014-11-25 Impact factor: 2.762
Authors: J De Reuck; F Auger; N Durieux; V Deramecourt; C Cordonnier; F Pasquier; C A Maurage; D Leys; R Bordet Journal: Aging Dis Date: 2015-11-17 Impact factor: 6.745
Authors: Karl G Helmer; Ofer Pasternak; Eli Fredman; Ronny I Preciado; Inga K Koerte; Takeshi Sasaki; Michael Mayinger; Andrew M Johnson; Jeffrey D Holmes; Lorie A Forwell; Elaine N Skopelja; Martha E Shenton; Paul S Echlin Journal: J Neurosurg Date: 2014-02-04 Impact factor: 5.115