AIM: To determine the impact of rotavirus immunisation on rotavirus hospitalisations in young children. methods: Annual hospitalisations for rotavirus gastroenteritis to The Children's Hospital at Westmead, a tertiary care paediatric hospital in Sydney, were recorded from 2001 for 6 years prior to and 2.5 years following the introduction of rotavirus vaccines to the National Immunisation Program. Data on hospital-acquired rotavirus gastroenteritis were collected prospectively. RESULTS: Hospitalisations for rotavirus gastroenteritis declined in the two full rotavirus seasons (2008 and 2009) after vaccine introduction by 75% compared with mean annual hospitalisations from 2001 to 2006. The greatest decline was seen in those <12 months of age (93%), but the reduction occurred consistently across all age groups, even in children not eligible for immunisation, suggesting an effect on herd immunity. A substantial decline in nosocomial rotavirus gastroenteritis was seen from 2007 to 2009, suggesting a reduction in virus transmission in the hospital setting. CONCLUSION: This study demonstrates a substantial reduction in hospitalisations in children of all ages to a large paediatric hospital and reduced nosocomial infections since the introduction of a nationally funded rotavirus immunisation programme in Australia.
AIM: To determine the impact of rotavirus immunisation on rotavirus hospitalisations in young children. methods: Annual hospitalisations for rotavirus gastroenteritis to The Children's Hospital at Westmead, a tertiary care paediatric hospital in Sydney, were recorded from 2001 for 6 years prior to and 2.5 years following the introduction of rotavirus vaccines to the National Immunisation Program. Data on hospital-acquired rotavirus gastroenteritis were collected prospectively. RESULTS: Hospitalisations for rotavirus gastroenteritis declined in the two full rotavirus seasons (2008 and 2009) after vaccine introduction by 75% compared with mean annual hospitalisations from 2001 to 2006. The greatest decline was seen in those <12 months of age (93%), but the reduction occurred consistently across all age groups, even in children not eligible for immunisation, suggesting an effect on herd immunity. A substantial decline in nosocomial rotavirus gastroenteritis was seen from 2007 to 2009, suggesting a reduction in virus transmission in the hospital setting. CONCLUSION: This study demonstrates a substantial reduction in hospitalisations in children of all ages to a large paediatric hospital and reduced nosocomial infections since the introduction of a nationally funded rotavirus immunisation programme in Australia.
Authors: E Anthony S Nelson; Ciro A de Quadros; Mathuram Santosham; Umesh D Parashar; Duncan Steele Journal: Hum Vaccin Immunother Date: 2013-08-16 Impact factor: 3.452
Authors: Parveen Fathima; Mark A Jones; Hannah C Moore; Christopher C Blyth; Robyn A Gibbs; Thomas L Snelling Journal: J Epidemiol Date: 2020-10-30 Impact factor: 3.211
Authors: Virginia E Pitzer; Katherine E Atkins; Birgitte Freiesleben de Blasio; Thierry Van Effelterre; Christina J Atchison; John P Harris; Eunha Shim; Alison P Galvani; W John Edmunds; Cécile Viboud; Manish M Patel; Bryan T Grenfell; Umesh D Parashar; Ben A Lopman Journal: PLoS One Date: 2012-08-13 Impact factor: 3.240