Literature DB >> 21243163

PET imaging of nobiletin based on a practical total synthesis.

Tomohiro Asakawa1, Aiki Hiza, Miho Nakayama, Makoto Inai, Dai Oyama, Hiroyuki Koide, Kosuke Shimizu, Toshiyuki Wakimoto, Norihiro Harada, Hideo Tsukada, Naoto Oku, Toshiyuki Kan.   

Abstract

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of (11)C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.

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Year:  2011        PMID： 21243163     DOI： 10.1039/c0cc04936k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways.

Authors:  Milad Ashrafizadeh; Ali Zarrabi; Sedigheh Saberifar; Farid Hashemi; Kiavash Hushmandi; Fardin Hashemi; Ebrahim Rahmani Moghadam; Reza Mohammadinejad; Masoud Najafi; Manoj Garg
Journal:  Biomedicines       Date:  2020-05-05

Review 2.  Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties.

Authors:  Kazuma Murakami; Kazuhiro Irie
Journal:  Molecules       Date:  2019-06-05       Impact factor: 4.411

3.  Beneficial effects of a nobiletin-rich formulated supplement of Sikwasa (C. depressa) peel on cognitive function in elderly Japanese subjects; A multicenter, randomized, double-blind, placebo-controlled study.

Authors:  Shizuo Yamada; Michiyo Shirai; Ken Ono; Toshiaki Teruya; Aki Yamano; Je Tae Woo
Journal:  Food Sci Nutr       Date:  2021-10-26       Impact factor: 2.863

4.  Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.

Authors:  Kosuke Shimizu; Tomohiro Asakawa; Norihiro Harada; Dai Fukumoto; Hideo Tsukada; Tomohiro Asai; Shizuo Yamada; Toshiyuki Kan; Naoto Oku
Journal:  PLoS One       Date:  2014-02-03       Impact factor: 3.240

Review 5.  Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies.

Authors:  Akira Nakajima; Yasushi Ohizumi; Kiyofumi Yamada
Journal:  Clin Psychopharmacol Neurosci       Date:  2014-08-12       Impact factor: 2.582

6.  Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents.

Authors:  Senling Feng; Huifang Zhou; Deyan Wu; Dechong Zheng; Biao Qu; Ruiming Liu; Chen Zhang; Zhe Li; Ying Xie; Hai-Bin Luo
Journal:  Acta Pharm Sin B       Date:  2019-07-31       Impact factor: 11.413

7.  Transdermal delivery of nobiletin using ionic liquids.

Authors:  Tadashi Hattori; Hiroki Tagawa; Makoto Inai; Toshiyuki Kan; Shin-Ichiro Kimura; Shigeru Itai; Samir Mitragotri; Yasunori Iwao
Journal:  Sci Rep       Date:  2019-12-27       Impact factor: 4.379
  7 in total

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