Literature DB >> 21242444

Provider response to a rare but highly publicized transmission of HIV through solid organ transplantation.

Lauren M Kucirka1, R Lorie Ros, Aruna K Subramanian, Robert A Montgomery, Dorry L Segev.   

Abstract

OBJECTIVE: On November 13, 2007, the first reported case in 20 years of HIV (human immunodeficiency virus) transmission from a Centers for Disease Control and Prevention high-risk donor (HRD) made national headlines. We sought to characterize change in the practice of transplant surgeons resulting from this rare event.
DESIGN: We performed a survey between January 17, 2008, and April 15, 2008, assessing attitudes and practices of transplant surgeons regarding HRDs. Descriptions of changes in practice after the event were categorized, and associations between responses and regional-, center-, and physician-level factors were studied.
SETTING: Transplant centers in the United States. PARTICIPANTS: Four hundred twenty-two transplant surgeons in current practice. MAIN OUTCOME MEASURE: Changing practice following the 2007 HIV transmission event.
RESULTS: Among surgeons who responded to the survey, 31.6% changed their practice following the event. Also, 41.7% decreased use of HRDs, 34.5% increased emphasis on informed consent, 16.7% increased use of nucleic acid testing, and 6.0% implemented a formal policy. Ranking fear of being sued or hospital pressure as important disincentives to HRD use was associated with more than 2-fold higher odds of changing practice. Ranking medical risks of HIV as an important disincentive was associated with 8.29-fold higher odds of decreasing HRD use.
CONCLUSION: The most common responses to this rare event were avoidance (decreased HRD use) and assurance (increased emphasis on informed consent) behaviors rather than patient safety measures (increased use of nucleic acid testing and implementation of formal policies), suggesting that fear of legal or regulatory consequences was the biggest driver of physician decision making and that the current litigious environment is failing to protect patient interests.

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Year:  2011        PMID: 21242444     DOI: 10.1001/archsurg.2010.303

Source DB:  PubMed          Journal:  Arch Surg        ISSN: 0004-0010


  9 in total

1.  Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act.

Authors:  Christine M Durand; Samantha E Halpern; Mary G Bowring; Gilad A Bismut; Oyinkansola T Kusemiju; Brianna Doby; Reinaldo E Fernandez; Charles S Kirby; Darin Ostrander; Peter G Stock; Shikha Mehta; Nicole A Turgeon; David Wojciechowski; Shirish Huprikar; Sander Florman; Shane Ottmann; Niraj M Desai; Andrew Cameron; Allan B Massie; Aaron A R Tobian; Andrew D Redd; Dorry L Segev
Journal:  Am J Transplant       Date:  2018-07-23       Impact factor: 8.086

Review 2.  Moving from the HIV Organ Policy Equity Act to HIV Organ Policy Equity in action: changing practice and challenging stigma.

Authors:  Brianna L Doby; Aaron A R Tobian; Dorry L Segev; Christine M Durand
Journal:  Curr Opin Organ Transplant       Date:  2018-04       Impact factor: 2.640

Review 3.  Risk of window period HIV infection in high infectious risk donors: systematic review and meta-analysis.

Authors:  L M Kucirka; H Sarathy; P Govindan; J H Wolf; T A Ellison; L J Hart; R A Montgomery; R L Ros; D L Segev
Journal:  Am J Transplant       Date:  2011-03-02       Impact factor: 8.086

4.  Utilizing increased risk for disease transmission (IRD) kidneys for pediatric renal transplant recipients.

Authors:  Christine S Hwang; Jyothsna Gattineni; Malcolm MacConmara
Journal:  Pediatr Nephrol       Date:  2019-06-26       Impact factor: 3.714

5.  Landscape of Deceased Donors Labeled Increased Risk for Disease Transmission Under New Guidelines.

Authors:  L M Kucirka; M G Bowring; A B Massie; X Luo; L H Nicholas; D L Segev
Journal:  Am J Transplant       Date:  2015-05-27       Impact factor: 8.086

Review 6.  Expanding deceased donor kidney transplantation: medical risk, infectious risk, hepatitis C virus, and HIV.

Authors:  Jessica M Ruck; Dorry L Segev
Journal:  Curr Opin Nephrol Hypertens       Date:  2018-11       Impact factor: 2.894

7.  The 3-T Model of Informed Consent for Nonstandard Risk Donors: A Proposal for Transplant Clinical Practice.

Authors:  Alessandra Agnese Grossi; Federico Nicoli; Tullia Maria De Feo; Massimo Cardillo; Gabriella Biffa; Renzo Pegoraro; Carlo Petrini; Rosanna Torelli; Francesca Puoti; Giuseppe Rossini; Giuseppe Piccolo; Sergio Vesconi; Enrico Minetti; Barbara Pozzo; Giuseppe Vanacore; David Paredes; Paolo Antonio Grossi; Mario Picozzi
Journal:  Transplant Direct       Date:  2021-10-22

8.  Consent to organ offers from public health service "Increased Risk" donors decreases time to transplant and waitlist mortality.

Authors:  Yvonne M Kelly; Arya Zarinsefat; Mehdi Tavakol; Amy M Shui; Chiung-Yu Huang; John P Roberts
Journal:  BMC Med Ethics       Date:  2022-03-05       Impact factor: 2.652

9.  Using machine learning to estimate survival curves for patients receiving an increased risk for disease transmission heart, liver, or lung versus waiting for a standard organ.

Authors:  Ethan Mark; David Goldsman; Pinar Keskinocak; Joel Sokol
Journal:  Transpl Infect Dis       Date:  2019-10-09
  9 in total

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