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Literature DB >> 21240405

A natural product-like inhibitor of NEDD8-activating enzyme.

Chung-Hang Leung¹, Daniel Shiu-Hin Chan, Hui Yang, Ruben Abagyan, Simon Ming-Yuen Lee, Guo-Yuan Zhu, Wang-Fun Fong, Dik-Lung Ma.

Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2011 PMID： 21240405 DOI： 10.1039/c0cc04927a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

15 in total

1. Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping.

Authors: Yu-Chen Chen; Max Totrov; Ruben Abagyan
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2. Congestion game scheduling for virtual drug screening optimization.

Authors: Natalia Nikitina; Evgeny Ivashko; Andrei Tchernykh
Journal: J Comput Aided Mol Des Date: 2017-12-20 Impact factor: 3.686

3. Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.

Authors: Bo Zhao; Keya Zhang; Eric B Villhauer; Karan Bhuripanyo; Hiroaki Kiyokawa; Hermann Schindelin; Jun Yin
Journal: Chembiochem Date: 2013-07-03 Impact factor: 3.164

4. Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.

Authors: Rajesh K Singh; Yaniv Kazansky; Donald Wathieu; David Fushman
Journal: Anal Chem Date: 2017-07-20 Impact factor: 6.986

5. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Authors: Jared T Hammill; Daniel C Scott; Jaeki Min; Michele C Connelly; Gloria Holbrook; Fangyi Zhu; Amy Matheny; Lei Yang; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal: J Med Chem Date: 2018-03-26 Impact factor: 7.446

6. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Authors: Jared T Hammill; Deepak Bhasin; Daniel C Scott; Jaeki Min; Yizhe Chen; Yan Lu; Lei Yang; Ho Shin Kim; Michele C Connelly; Courtney Hammill; Gloria Holbrook; Cynthia Jeffries; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal: J Med Chem Date: 2018-03-26 Impact factor: 7.446

A natural product-like inhibitor of NEDD8-activating enzyme.

1. Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping.

2. Congestion game scheduling for virtual drug screening optimization.

3. Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.

4. Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.

5. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

6. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

7. Hit identification of IKKβ natural product inhibitor.

8. Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening.

9. Small molecules targeting the NEDD8·NAE protein-protein interaction.

10. A metal-based inhibitor of NEDD8-activating enzyme.