Literature DB >> 21240342

Effects of lipoic acid on proliferation and apoptosis of liver cells in rats with metabolic stress.

E A Martinova1, A V Vasiliev, N E Sharanova, M M Gapparov.   

Abstract

Lipoic acid stimulated expression of heat shock proteins 25, 70, and 90 in liver cells of Wistar rats with metabolic stress (5 days of food deprivation followed by complete resumption of nutrition). Lipoic acid in a dose of 25 mg/kg reduced proliferation of hepatic lymphocytes during fasting, while after resumption of feeding it stimulated hepatocyte proliferation due to differentiated regulation of the expression of cyclin D1 and Rb protein in these cell populations.

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Year:  2011        PMID: 21240342     DOI: 10.1007/s10517-011-1130-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  1 in total

1.  Alfa-lipoic acid controls tumor growth and modulates hepatic redox state in Ehrlich-ascites-carcinoma-bearing mice.

Authors:  M Al Abdan
Journal:  ScientificWorldJournal       Date:  2012-05-01
  1 in total

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