| Literature DB >> 21240066 |
Jianlan Sun1, L Jeffrey Medeiros, Pei Lin, Gary Lu, Carlos E Bueso-Ramos, M James You.
Abstract
Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.Entities:
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Year: 2011 PMID： 21240066 DOI： 10.1097/PAT.0b013e328340bbba
Source DB: PubMed Journal: Pathology ISSN： 0031-3025 Impact factor: 5.306