Literature DB >> 21239776

Evidence-based mini-review: the role of alkylating agents in the initial treatment of chronic lymphocytic leukemia patients with the 11q deletion.

Wei Ding1, Alessandra Ferrajoli.   

Abstract

A 55-year-old man presented with fever, night sweats, and weight loss of about 20 lbs. in the prior 6 months. Physical examination revealed multiple cervical, axillary, and inguinal lymphadenopathy. The spleen was enlarged. A complete blood count revealed leukocytosis with absolute lymphocytosis: 30,000/μL. Peripheral blood-flow cytometric analysis showed a clonal lymphocyte population with immunophenotypes positive for CD5, CD20(dim), and monotypic kappa light chain. Fluorescence in situ hybridization (FISH) analysis revealed del(11q22.3), but negative for t(11:14). What should be used to treat his chronic lymphocytic leukemia (CLL) disease?

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Year:  2010        PMID： 21239776     DOI： 10.1182/asheducation-2010.1.90

Source DB:  PubMed          Journal:  Hematology Am Soc Hematol Educ Program        ISSN： 1520-4383


  6 in total

Review 1.  Can prognostic factors be used to direct therapy in chronic lymphocytic leukemia?

Authors:  Leopold Sellner; Sascha Dietrich; Peter Dreger; Hanno Glimm; Thorsten Zenz
Journal:  Curr Hematol Malig Rep       Date:  2012-03       Impact factor: 3.952

2.  Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997.

Authors:  Mitchell R Smith; Donna Neuberg; Ian W Flinn; Michael R Grever; Hillard M Lazarus; Jacob M Rowe; Gordon Dewald; John M Bennett; Elisabeth M Paietta; John C Byrd; Mohamad A Hussein; Frederick R Appelbaum; Richard A Larson; Mark R Litzow; Martin S Tallman
Journal:  Blood       Date:  2011-07-29       Impact factor: 22.113

3.  ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.

Authors:  Anna Guarini; Marilisa Marinelli; Simona Tavolaro; Emanuele Bellacchio; Monia Magliozzi; Sabina Chiaretti; Maria Stefania De Propris; Nadia Peragine; Simona Santangelo; Francesca Paoloni; Mauro Nanni; Ilaria Del Giudice; Francesca Romana Mauro; Isabella Torrente; Robin Foà
Journal:  Haematologica       Date:  2011-10-11       Impact factor: 9.941

4.  In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow.

Authors:  Sabine Wislet-Gendebien; Christophe Poulet; Virginie Neirinckx; Benoit Hennuy; James T Swingland; Emerence Laudet; Lukas Sommer; Olga Shakova; Vincent Bours; Bernard Rogister
Journal:  PLoS One       Date:  2012-10-05       Impact factor: 3.240

5.  Chronic lymphocytic leukemia in young (≤ 55 years) patients: a comprehensive analysis of prognostic factors and outcomes.

Authors:  Sameer A Parikh; Kari G Rabe; Neil E Kay; Timothy G Call; Wei Ding; Susan M Schwager; Deborah A Bowen; Michael Conte; Diane F Jelinek; Susan L Slager; Tait D Shanafelt
Journal:  Haematologica       Date:  2013-08-02       Impact factor: 9.941

6.  Modern treatment in chronic lymphocytic leukemia: impact on survival and efficacy in high-risk subgroups.

Authors:  Antonio Cuneo; Francesco Cavazzini; Maria Ciccone; Giulia Daghia; Olga Sofritti; Elena Saccenti; Massimo Negrini; Gian Matteo Rigolin
Journal:  Cancer Med       Date:  2014-03-19       Impact factor: 4.452
  6 in total

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