| Literature DB >> 21239064 |
Marina A Gruden1, Robert D E Sewell, Kiran Yanamandra, Tatyana V Davidova, Valery G Kucheryanu, Evgeny V Bocharov, Olga A Bocharova, Olga R Bocharova, Vsevolod V Polyschuk, Vladimir V Sherstnev, Ludmilla A Morozova-Roche.
Abstract
The aim was to ascertain any possible linkage between humoral immune responses to principal biomarkers (α-synuclein monomers, its toxic oligomers or fibrils, dopamine and S100B) and cellular immunity in Parkinson's disease development. There were elevated autoantibody titers to α-synuclein monomers, oligomers plus fibrils in 72%, 56%, and 17% of Parkinsonian patients respectively with a 5-year disease duration. Additionally, there were increased titers to dopamine and S100B (96% and 89%) in the 5-year patient group. All of these values subsided in 10-year sufferers. Furthermore, CD3+, CD4+, CD8+ T-lymphocyte and B-lymphocyte subsets declined in the patient cohort during Parkinsonism indicating disease associated reductions in these lymphocyte subsets.Entities:
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Year: 2011 PMID： 21239064 DOI： 10.1016/j.jneuroim.2010.12.001
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478