Esther Zimmermann1, Rodolphe Anty2, Joan Tordjman3, An Verrijken4, Philippe Gual2, Albert Tran2, Antonio Iannelli2, Jean Gugenheim2, Pierre Bedossa5, Sven Francque6, Yannick Le Marchand-Brustel2, Karine Clement3, Luc Van Gaal4, Thorkild I A Sørensen7, Tine Jess8. 1. Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark; Institute of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address: ez@ipm.regionh.dk. 2. Institut National de la Santé et de la Recherche Médicale (INSERM), U895, Team 8, "Hepatic Complications in Obesity", Nice, F-06204 Cedex 3, France; Centre Hospitalier Universitaire of Nice, Digestive Center, Nice, F-06202 Cedex 3, France; University of Nice-Sophia-Antipolis, Faculty of Medicine, Nice, F-06107 Cedex 2, France. 3. INSERM, Nutriomique, U872, Paris F-75006, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris 6, UMR S 872, Paris F-75006, France; Université Paris Descartes, UMR S 872, Paris F-75006, France; Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris F-75013, France; CRNH-Ile de France, Paris F-75013, France. 4. Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium. 5. Assistance Publique-Hôpitaux de Paris, Beaujon Hospital, Pathology Department, Clichy F-92110, France; Centre de Recherche Bichat-Beaujon, INSERM U773, Clichy F-92110, France. 6. Department of Gastroenterology and Hepatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium. 7. Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. 8. Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: TJS@ssi.dk.
Abstract
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. METHODS: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. RESULTS: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p<0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p<0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. CONCLUSIONS: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients.
BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obesepatients. METHODS: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. RESULTS: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p<0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p<0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. CONCLUSIONS: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obesepatients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obesepatients.
Authors: Tracey G Simon; Maria Esther Perez Trejo; Robyn McClelland; Ryan Bradley; Michael J Blaha; Irfan Zeb; Kathleen E Corey; Matthew J Budoff; Raymond T Chung Journal: Int J Cardiol Date: 2018-05-15 Impact factor: 4.164
Authors: Yasmin S Hamirani; Ronit Katz; Khurram Nasir; Irfan Zeb; Michael J Blaha; Roger S Blumenthal; Richard N Kronmal; Matthew J Budoff Journal: J Clin Exp Cardiolog Date: 2014
Authors: Sara E Stinson; Anna E Jonsson; Morten A V Lund; Christine Frithioff-Bøjsøe; Louise Aas Holm; Oluf Pedersen; Lars Ängquist; Thorkild I A Sørensen; Jens J Holst; Michael Christiansen; Jens-Christian Holm; Bolette Hartmann; Torben Hansen Journal: J Clin Endocrinol Metab Date: 2021-05-13 Impact factor: 5.958
Authors: Piero Portincasa; Leonilde Bonfrate; Mohamad Khalil; Maria De Angelis; Francesco Maria Calabrese; Mauro D'Amato; David Q-H Wang; Agostino Di Ciaula Journal: Biomedicines Date: 2021-12-31
Authors: Jacinda M Nicklas; Frank M Sacks; Steven R Smith; Meryl S LeBoff; Jennifer C Rood; George A Bray; Paul M Ridker Journal: Obesity (Silver Spring) Date: 2013-04 Impact factor: 5.002