Literature DB >> 21237644

Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.

Guiying Li1, Hao Zhou, Yu Jiang, Holger Keim, Sidney W Topiol, Suresh B Poda, Yong Ren, Gamini Chandrasena, Darío Doller.   

Abstract

Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT(1) and MT(2) receptors are reported. Compounds 11f and 18b (MT(1)/MT(2) agonist) have human microsomal intrinsic clearance comparable to ramelteon.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21237644     DOI： 10.1016/j.bmcl.2010.12.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Integrating In Silico and In Vitro Approaches to Screen the Antidiabetic Properties from Tabernaemontana divaricata (Jasmine) Flowers.

Authors:  Saima Muzammil; Rahat Andleeb; Sumreen Hayat; Muhammad Umar Ijaz; Asma Ashraf; Nimrah Zafar; Shabana Naz; Mubashera Shaheen
Journal:  Evid Based Complement Alternat Med       Date:  2022-05-31       Impact factor: 2.650

Review 2.  Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.

Authors:  Paula Ruiz-Castillo; Stephen L Buchwald
Journal:  Chem Rev       Date:  2016-09-30       Impact factor: 60.622

3.  Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines.

Authors:  Syed Sikander Azam; Sumra Wajid Abbasi
Journal:  Theor Biol Med Model       Date:  2013-10-24       Impact factor: 2.432

Review 4.  Synthetic melatoninergic ligands: achievements and prospects.

Authors:  N V Kostiuk; M B Belyakova; D V Leshchenko; V V Zhigulina; M V Miniaev
Journal:  ISRN Biochem       Date:  2014-02-23
  4 in total

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