BACKGROUND: Cytomegalovirus (CMV) infection has been shown to occur not rarely in critically ill patients in the past decade. However, little data are available on CMV infection in burn patients whereas their susceptibility to CMV infection has been proved. METHODS: We prospectively assessed CMV viremia by real-time polymerase chain reaction and clinical outcome in immunocompetent burn patients with total burn surface area greater than 15%. RESULTS: Twenty-nine patients were enrolled. The rate of CMV infection was of 71% in CMV seropositive burn patients, and of 12.5% in CMV seronegative burn patients. CMV reactivation was associated with a higher IGS 2 score on admission. High grade CMV viremia was associated with longer mechanical ventilation duration, higher infection number, higher transfused red blood cell number, and longer ICU stays. There were no differences on mortality rate between patients with and without CMV reactivation. CONCLUSION: CMV infection rate is considerable in burn patients with TBSA greater than 15%. This infection seems to be mostly due to reactivation of latently existing virus.
BACKGROUND:Cytomegalovirus (CMV) infection has been shown to occur not rarely in critically illpatients in the past decade. However, little data are available on CMV infection in burn patients whereas their susceptibility to CMV infection has been proved. METHODS: We prospectively assessed CMV viremia by real-time polymerase chain reaction and clinical outcome in immunocompetent burn patients with total burn surface area greater than 15%. RESULTS: Twenty-nine patients were enrolled. The rate of CMV infection was of 71% in CMV seropositive burn patients, and of 12.5% in CMV seronegative burn patients. CMV reactivation was associated with a higher IGS 2 score on admission. High grade CMV viremia was associated with longer mechanical ventilation duration, higher infection number, higher transfused red blood cell number, and longer ICU stays. There were no differences on mortality rate between patients with and without CMV reactivation. CONCLUSION:CMV infection rate is considerable in burn patients with TBSA greater than 15%. This infection seems to be mostly due to reactivation of latently existing virus.
Authors: Sara Mansfield; Varun Dwivedi; Sara Byrd; Joanne Trgovcich; Marion Griessl; Michael Gutknecht; Charles H Cook Journal: J Med Virol Date: 2016-02-02 Impact factor: 2.327
Authors: Paul Wurzer; Ashley Guillory; Daryousch Parvizi; Robert P Clayton; Ludwik K Branski; Lars-P Kamolz; Celeste C Finnerty; David N Herndon; Jong O Lee Journal: Burns Date: 2016-08-08 Impact factor: 2.744
Authors: Julien Bordes; Philippe Goutorbe; Ambroise Montcriol; Henry Boret; Eric Dantzer; Eric Meaudre Journal: Crit Care Date: 2014-02-25 Impact factor: 9.097
Authors: Josef Haik; Gil Nardini; Noga Goldman; Gilli Galore-Haskel; Moti Harats; Isaac Zilinsky; Oren Weissman; Jacob Schachter; Eyal Winkler; Gal Markel Journal: Oncotarget Date: 2016-01-19
Authors: David S Y Ong; Cristian Spitoni; Peter M C Klein Klouwenberg; Frans M Verduyn Lunel; Jos F Frencken; Marcus J Schultz; Tom van der Poll; Jozef Kesecioglu; Marc J M Bonten; Olaf L Cremer Journal: Intensive Care Med Date: 2015-09-28 Impact factor: 17.440