OBJECTIVES: To assess long-term neurodevelopmental outcome of adolescents with congenital heart disease after open-heart surgery and to evaluate whether deficits are associated with cerebral injury detectable on magnetic resonance imaging (MRI). STUDY DESIGN: We conducted a cohort study with longitudinal follow-up of 53 adolescents (mean age, 13.7 years; range, 11.4 to 16.9 years) who had undergone open-heart surgery with full-flow cardiopulmonary bypass during childhood and compared them with 41 age-matched controls. Assessment included conventional MRI and neurodevelopmental testing. RESULTS: MRI abnormalities were detected in 11 of the 53 patients (21%), comprising predominately white matter abnormalities and volume loss. Neurodevelopmental outcome was impaired in several domains, including neuromotor, intellectual, and executive functions, as well as visuomotor perception and integration. Adolescents with cerebral abnormalities had greater impairment in most neurodevelopmental domains compared with those without cerebral abnormalities. CONCLUSIONS: Cerebral abnormalities can be detected in a significant proportion of adolescents with corrected congenital heart disease. These abnormalities are found predominately in the white matter and are apparently of hypoxic-ischemic origin, most likely acquired during the neonatal period.
OBJECTIVES: To assess long-term neurodevelopmental outcome of adolescents with congenital heart disease after open-heart surgery and to evaluate whether deficits are associated with cerebral injury detectable on magnetic resonance imaging (MRI). STUDY DESIGN: We conducted a cohort study with longitudinal follow-up of 53 adolescents (mean age, 13.7 years; range, 11.4 to 16.9 years) who had undergone open-heart surgery with full-flow cardiopulmonary bypass during childhood and compared them with 41 age-matched controls. Assessment included conventional MRI and neurodevelopmental testing. RESULTS:MRI abnormalities were detected in 11 of the 53 patients (21%), comprising predominately white matter abnormalities and volume loss. Neurodevelopmental outcome was impaired in several domains, including neuromotor, intellectual, and executive functions, as well as visuomotor perception and integration. Adolescents with cerebral abnormalities had greater impairment in most neurodevelopmental domains compared with those without cerebral abnormalities. CONCLUSIONS:Cerebral abnormalities can be detected in a significant proportion of adolescents with corrected congenital heart disease. These abnormalities are found predominately in the white matter and are apparently of hypoxic-ischemic origin, most likely acquired during the neonatal period.
Authors: Michael J Rivkin; Christopher G Watson; Lisa A Scoppettuolo; David Wypij; Sridhar Vajapeyam; David C Bellinger; David R DeMaso; Richard L Robertson; Jane W Newburger Journal: J Thorac Cardiovasc Surg Date: 2013-02-01 Impact factor: 5.209
Authors: Anastasia Dimitropoulos; Patrick S McQuillen; Viyeka Sethi; Alisha Moosa; Vann Chau; Duan Xu; Rollin Brant; Anthony Azakie; Andrew Campbell; A James Barkovich; Kenneth J Poskitt; Steven P Miller Journal: Neurology Date: 2013-06-14 Impact factor: 9.910
Authors: Caitlin K Rollins; Christopher G Watson; Lisa A Asaro; David Wypij; Sridhar Vajapeyam; David C Bellinger; David R DeMaso; Richard L Robertson; Jane W Newburger; Michael J Rivkin Journal: J Pediatr Date: 2014-09-10 Impact factor: 4.406
Authors: Christopher G Watson; Lisa A Asaro; David Wypij; Richard L Robertson; Jane W Newburger; Michael J Rivkin Journal: J Pediatr Date: 2015-11-06 Impact factor: 4.406
Authors: Benjamin Asschenfeldt; Lars Evald; Johan Heiberg; Camilla Salvig; Leif Østergaard; Rikke Beese Dalby; Simon Fristed Eskildsen; Vibeke Elisabeth Hjortdal Journal: J Am Heart Assoc Date: 2020-05-19 Impact factor: 5.501