Literature DB >> 21235245

Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines.

Georgette M Castanedo1, Pamela S Seng, Nicole Blaquiere, Sean Trapp, Steven T Staben.   

Abstract

A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.
© 2011 American Chemical Society

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Year:  2011        PMID： 21235245     DOI： 10.1021/jo1023393

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  11 in total

Review 1.  Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.

Authors:  Simpal Kumari; Dharma Kishore; Sarvesh Paliwal; Rajani Chauhan; Jaya Dwivedi; Aakanksha Mishra
Journal:  Mol Divers       Date:  2015-06-09       Impact factor: 2.943

2.  Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates.

Authors:  Jonas Sävmarker; Jonas Rydfjord; Johan Gising; Luke R Odell; Mats Larhed
Journal:  Org Lett       Date:  2012-04-17       Impact factor: 6.005

3.  One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles.

Authors:  Dmytro S Radchenko; Vasyl S Naumchyk; Igor Dziuba; Andrii A Kyrylchuk; Kateryna E Gubina; Yurii S Moroz; Oleksandr O Grygorenko
Journal:  Mol Divers       Date:  2021-04-02       Impact factor: 3.364

Review 4.  Diversity oriented syntheses of conventional heterocycles by smart multi component reactions (MCRs) of the last decade.

Authors:  Heiner Eckert
Journal:  Molecules       Date:  2012-01-20       Impact factor: 4.411

5.  Efficient Copper-Catalyzed Multicomponent Synthesis of N-Acyl Amidines via Acyl Nitrenes.

Authors:  Kaj M van Vliet; Lara H Polak; Maxime A Siegler; Jarl Ivar van der Vlugt; Célia Fonseca Guerra; Bas de Bruin
Journal:  J Am Chem Soc       Date:  2019-09-10       Impact factor: 15.419

6.  A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression.

Authors:  Yuan He; Weiqiong Kan; Yunqi Li; Yun Hao; Anling Huang; Haijun Gu; Minna Wang; Qingqing Wang; Jinlian Chen; Zhenliang Sun; Mingyao Liu; Yihua Chen; Zhengfang Yi
Journal:  Clin Transl Med       Date:  2021-02

7.  Direct intramolecular double cross-dehydrogentive-coupling (CDC) cyclization of N-(2-pyridyl)amidines under metal-free conditions.

Authors:  Fengping Yi; Chao Fu; Qihui Sun; Huazhen Wei; Genfa Yu; Weiyin Yi
Journal:  RSC Adv       Date:  2019-12-19       Impact factor: 3.361

8.  Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system.

Authors:  Zitong Zhou; Yu Zhao; Donghua Zhou; Li Li; Hui Luo; Liao Cui; Weiguang Yang
Journal:  RSC Adv       Date:  2021-10-18       Impact factor: 4.036

9.  Decarboxylative palladium(II)-catalyzed synthesis of aryl amidines from aryl carboxylic acids: development and mechanistic investigation.

Authors:  Jonas Rydfjord; Fredrik Svensson; Alejandro Trejos; Per J R Sjöberg; Christian Sköld; Jonas Sävmarker; Luke R Odell; Mats Larhed
Journal:  Chemistry       Date:  2013-08-28       Impact factor: 5.236

10.  Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.

Authors:  Martina Kulén; Carlos Núñez-Otero; Andrew G Cairns; Jim Silver; Anders E G Lindgren; Emma Wede; Pardeep Singh; Katarina Vielfort; Wael Bahnan; James A D Good; Richard Svensson; Sven Bergström; Åsa Gylfe; Fredrik Almqvist
Journal:  Medchemcomm       Date:  2019-10-17       Impact factor: 3.597
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