Jan Philipp Benthien1, Peter Behrens. 1. Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland, jbenthien@uhbs.ch
Abstract
PURPOSE: Articular resurfacing by treatment of chondral defects may include chondral abrasion, autologous chondrocyte Implantation (ACI), matrix-induced chondrocyte transplantation (MACT) or osteochondral autologous transplantation (OATS). This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures. METHODS: This is a technical note on the AMIC procedure and its further development. RESULTS AND CONCLUSION: This method is applied primarily in chondral or osteochondral lesions of the knee. Indications and contraindications are provided; the technique is described. The further development of AMIC is described with an increased focus on the subchondral zone and the complex of cartilage and bone, the osteochondral unit, which receives increased attention in cartilage research. LEVEL OF EVIDENCE: IV.
PURPOSE: Articular resurfacing by treatment of chondral defects may include chondral abrasion, autologous chondrocyte Implantation (ACI), matrix-induced chondrocyte transplantation (MACT) or osteochondral autologous transplantation (OATS). This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures. METHODS: This is a technical note on the AMIC procedure and its further development. RESULTS AND CONCLUSION: This method is applied primarily in chondral or osteochondral lesions of the knee. Indications and contraindications are provided; the technique is described. The further development of AMIC is described with an increased focus on the subchondral zone and the complex of cartilage and bone, the osteochondral unit, which receives increased attention in cartilage research. LEVEL OF EVIDENCE: IV.
Authors: Kai Mithoefer; Riley J Williams; Russell F Warren; Hollis G Potter; Christopher R Spock; Edward C Jones; Thomas L Wickiewicz; Robert G Marx Journal: J Bone Joint Surg Am Date: 2005-09 Impact factor: 5.284
Authors: P Behrens; U Bosch; J Bruns; C Erggelet; S A Esenwein; C Gaissmaier; T Krackhardt; J Löhnert; S Marlovits; N M Meenen; J Mollenhauer; S Nehrer; F U Niethard; U Nöth; C Perka; W Richter; D Schäfer; U Schneider; M Steinwachs; K Weise Journal: Z Orthop Ihre Grenzgeb Date: 2004 Sep-Oct
Authors: Eleftherios A Makris; Andreas H Gomoll; Konstantinos N Malizos; Jerry C Hu; Kyriacos A Athanasiou Journal: Nat Rev Rheumatol Date: 2014-09-23 Impact factor: 20.543