Epidemiology of smoking-related malignancies.

It is well known that tobacco use is the major single cause of cancer mortality. Cigarette smokers have increased risk for cancer of the lung, bladder, oral cavity and pharynx, pancreas, kidney, larynx, and esophagus. Although smoking is the primary risk factor for several of the malignancies, each tumour site has other known or suspected risk factors. The author describes the smoking association for each tumour site and reviews other risk factors for these smoking-related malignancies.