| Literature DB >> 21232953 |
Andrés A Trabanco1, Guillaume Duvey, José María Cid, Gregor J Macdonald, Philippe Cluzeau, Vanthea Nhem, Rocco Furnari, Nadia Behaj, Géraldine Poulain, Terry Finn, Hilde Lavreysen, Sonia Poli, Alexandre Raux, Yves Thollon, Nicolas Poirier, David D'Addona, José Ignacio Andrés, Robert Lutjens, Emmanuel Le Poul, Hassan Imogai, Jean-Philippe Rocher.
Abstract
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described.Entities:
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Year: 2010 PMID： 21232953 DOI： 10.1016/j.bmcl.2010.12.048
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823