OBJECTIVE: To test the hypothesis that very low birth weight (VLBW) and extremely low birth weight (ELBW) infants have an increased incidence of congenital hypothyroidism (CH) with a delayed thyroid-stimulating hormone (TSH) elevation and that the outcomes of these infants are similar to control infants. STUDY DESIGN: Retrospective analysis of newborn thyroid screening data for 92 800 live births in Rhode Island to identify CH with a delayed TSH elevation. Developmental, growth, and endocrine outcomes of the index cases were assessed at 18 months corrected age. RESULTS: CH with a delayed TSH elevation occurred in 1 in 58 ELBW, 1 in 95 VLBW, and 1 in 30 329 infants weighing ≥1500 grams (P < .0001). The incidence of head circumference <10(th) percentile was higher in VLBW infants with CH associated with a delayed TSH elevation (P < .05), and the mean head circumferences, weights, lengths, and developmental scores were similar to matched control infants. Three infants received short-term levothyroxine replacement. CONCLUSIONS: The incidence of CH with a delayed TSH elevation was higher in ELBW and VLBW infants compared with infants weighing ≥1500 grams. The outcomes of these infants were comparable with matched control infants.
OBJECTIVE: To test the hypothesis that very low birth weight (VLBW) and extremely low birth weight (ELBW) infants have an increased incidence of congenital hypothyroidism (CH) with a delayed thyroid-stimulating hormone (TSH) elevation and that the outcomes of these infants are similar to control infants. STUDY DESIGN: Retrospective analysis of newborn thyroid screening data for 92 800 live births in Rhode Island to identify CH with a delayed TSH elevation. Developmental, growth, and endocrine outcomes of the index cases were assessed at 18 months corrected age. RESULTS: CH with a delayed TSH elevation occurred in 1 in 58 ELBW, 1 in 95 VLBW, and 1 in 30 329 infants weighing ≥1500 grams (P < .0001). The incidence of head circumference <10(th) percentile was higher in VLBW infants with CH associated with a delayed TSH elevation (P < .05), and the mean head circumferences, weights, lengths, and developmental scores were similar to matched control infants. Three infants received short-term levothyroxine replacement. CONCLUSIONS: The incidence of CH with a delayed TSH elevation was higher in ELBW and VLBW infants compared with infants weighing ≥1500 grams. The outcomes of these infants were comparable with matched control infants.
Authors: George A Ford; Sara Denniston; David Sesser; Michael R Skeels; Stephen H LaFranchi Journal: Horm Res Paediatr Date: 2016-09-06 Impact factor: 2.852
Authors: Alex R Kemper; Scott D Grosse; Mei Baker; Allison J Pollock; Cynthia F Hinton; Stuart K Shapira Journal: J Pediatr Date: 2020-05-11 Impact factor: 4.406
Authors: Susan R Rose; Christopher E Blunden; Olumide O Jarrett; Kyle Kaplan; Rheta Caravantes; Henry T Akinbi Journal: J Pediatr Date: 2021-11-06 Impact factor: 4.406
Authors: A Cassio; C Corbetta; I Antonozzi; F Calaciura; U Caruso; G Cesaretti; R Gastaldi; E Medda; F Mosca; E Pasquini; M C Salerno; V Stoppioni; M Tonacchera; G Weber; A Olivieri Journal: J Endocrinol Invest Date: 2013-02-12 Impact factor: 4.256