Literature DB >> 2123

Action of six commonly used benzodiazepines on isolated guinea-pig ileum preparation.

S Huck, G Stacher, G Gogolák, C Stumpf.   

Abstract

The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.

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Year:  1975        PMID: 2123

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN: 0003-9780


  1 in total

1.  Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects.

Authors:  F B Eatman; W A Colburn; H G Boxenbaum; H N Posmanter; R E Weinfeld; R Ronfeld; L Weissman; J D Moore; M Gibaldi; S A Kaplan
Journal:  J Pharmacokinet Biopharm       Date:  1977-10
  1 in total

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