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Literature DB >> 21229975

Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6.

Anna Wieckowska¹, Rebecca Fransson, Luke R Odell, Mats Larhed.

Abstract

A simple and expedient process for the Heck aminocarbonylative synthesis of Weinreb and MAP amide acylating agents, from aryl halides, is reported. This methodology utilizes solid sources of CO making it readily accessible to chemists working in small-scale laboratory applications.

Entities: Chemical

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Year: 2011 PMID： 21229975 DOI： 10.1021/jo102151u

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

6 in total

1. Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles.

Authors: Francis J Barrios; Brannon C Springer; Robert A Hazlitt; David A Colby
Journal: Synthesis (Stuttg) Date: 2014-12-05 Impact factor: 3.157

2. Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.

Authors: Zhuming Zhang; Peter J Connolly; Luis Trabalón Escolar; Christian Rocaboy; Vineet Pande; Lieven Meerpoel; Heng-Keang Lim; Jonathan R Branch; Janine Ondrus; Ian Hickson; Tammy L Bush; James R Bischoff; Gilles Bignan
Journal: ACS Med Chem Lett Date: 2021-06-29 Impact factor: 4.632

3. Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide.

Authors: Linda Åkerbladh; Shiao Y Chow; Luke R Odell; Mats Larhed
Journal: ChemistryOpen Date: 2017-08-16 Impact factor: 2.911

Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6.

1. Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles.

2. Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.

3. Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide.

Review 4. Heterogeneous Phase Microwave-Assisted Reactions under CO₂ or CO Pressure.

5. Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes.

6. N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands.