Literature DB >> 21228988

Presymptomatic Diagnosis of Genetic Disorders: Is it worth the anxiety?

T N Tannenbaum, E E Rosenberg.   

Abstract

Through recent advances in DNA technology, presymptomatic diagnosis of several genetic disorders is now possible. This technology can determine whether an at-risk individual is at greatly increased risk of having inherited the gene for a particular disorder many years before symptoms are expected to occur. To provide effective care, the family physician must be aware of the potential benefits and risks of presymptomatic testing.

Entities:  

Year:  1991        PMID： 21228988      PMCID： PMC2145256     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  28 in total

1.  Localization of a susceptibility locus for schizophrenia on chromosome 5.

Authors:  R Sherrington; J Brynjolfsson; H Petursson; M Potter; K Dudleston; B Barraclough; J Wasmuth; M Dobbs; H Gurling
Journal:  Nature       Date:  1988-11-10       Impact factor: 49.962

2.  Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.

Authors:  S T Reeders; M H Breuning; G Corney; S J Jeremiah; P Meera Khan; K E Davies; D A Hopkinson; P L Pearson; D J Weatherall
Journal:  Br Med J (Clin Res Ed)       Date:  1986-03-29

3.  Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria.

Authors:  A G DiLella; J Marvit; A S Lidsky; F Güttler; S L Woo
Journal:  Nature       Date:  1986 Aug 28-Sep 3       Impact factor: 49.962

4.  Predictive testing for Huntington's disease with use of a linked DNA marker.

Authors:  G J Meissen; R H Myers; C A Mastromauro; W J Koroshetz; K W Klinger; L A Farrer; P A Watkins; J F Gusella; E D Bird; J B Martin
Journal:  N Engl J Med       Date:  1988-03-03       Impact factor: 91.245

5.  A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16.

Authors:  S T Reeders; M H Breuning; K E Davies; R D Nicholls; A P Jarman; D R Higgs; P L Pearson; D J Weatherall
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

6.  Improved predictive testing for Huntington disease by using three linked DNA markers.

Authors:  M R Hayden; C Robbins; D Allard; J Haines; S Fox; J Wasmuth; M Fahy; M Bloch
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

7.  Intended use of predictive testing by those at risk for Huntington disease.

Authors:  G J Meissen; R L Berchek
Journal:  Am J Med Genet       Date:  1987-02

8.  Attitudes toward presymptomatic testing in Huntington disease.

Authors:  C Mastromauro; R H Myers; B Berkman
Journal:  Am J Med Genet       Date:  1987-02

9.  Attitudes of persons at risk for Huntington disease toward predictive testing.

Authors:  S Kessler; T Field; L Worth; H Mosbarger
Journal:  Am J Med Genet       Date:  1987-02

10.  At-risk persons' attitudes toward presymptomatic and prenatal testing of Huntington disease in Michigan.

Authors:  D S Markel; A B Young; J B Penney
Journal:  Am J Med Genet       Date:  1987-02
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