Literature DB >> 212288

Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase.

A Beretz, R Anton, J C Stoclet.   

Abstract

The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of which have a potency equivalent to that of papaverine. Some structure activity relationships are drawn.

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Year:  1978        PMID： 212288     DOI： 10.1007/bf01915343

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids.

Authors:  R T Borchardt; J A Huber
Journal:  J Med Chem       Date:  1975-01       Impact factor: 7.446

Review 2.  Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents.

Authors:  B Weiss; W N Hait
Journal:  Annu Rev Pharmacol Toxicol       Date:  1977       Impact factor: 13.820

3.  Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine.

Authors:  G L Kramer; J E Garst; S S Mitchel; J N Wells
Journal:  Biochemistry       Date:  1977-07-26       Impact factor: 3.162

4.  Cyclic nucleotide phosphodiesterase inhibition and vascular smooth muscle relaxation.

Authors:  C Lugnier; Y Bertrand; J C Stoclet
Journal:  Eur J Pharmacol       Date:  1972-07       Impact factor: 4.432

5.  Inhibition of lens aldose reductase by flavonoids--their possible role in the prevention of diabetic cataracts.

Authors:  S D Varma; J H Kinoshita
Journal:  Biochem Pharmacol       Date:  1976-11-15       Impact factor: 5.858

6.  Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells.

Authors:  C M Fewtrell; B D Gomperts
Journal:  Nature       Date:  1977-02-17       Impact factor: 49.962

7.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

8.  Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles.

Authors:  D R Lang; E Racker
Journal:  Biochim Biophys Acta       Date:  1974-02-22

9.  Inhibition of (Na+, K+)adenosine triphosphatase and its partial reactions by quercetin.

Authors:  Y Kuriki; E Racker
Journal:  Biochemistry       Date:  1976-11-16       Impact factor: 3.162

10.  Pig heart mitochondrial ATPase : properties of purified and membrane-bound enzyme. Effects of flavonoids.

Authors:  A Di Pietro; C Godinot; M L Bouillant; D C Gautheron
Journal:  Biochimie       Date:  1975       Impact factor: 4.079
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  19 in total

1.  The effect of naringenin on the intestinal and renal transport of organic solutes.

Authors:  J W Robinson; M L'Herminier; H G Claudet
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

2.  Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.

Authors:  Francisco Orallo; Ezequiel Alvarez; Hélène Basaran; Claire Lugnier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-11-17       Impact factor: 3.000

Review 3.  Wine as a biological fluid: history, production, and role in disease prevention.

Authors:  G J Soleas; E P Diamandis; D M Goldberg
Journal:  J Clin Lab Anal       Date:  1997       Impact factor: 2.352

4.  Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases.

Authors:  K Shinozuka; Y Kikuchi; C Nishino; A Mori; S Tawata
Journal:  Experientia       Date:  1988-10-15

Review 5.  On the action of combination bronchodilators.

Authors:  C J Hanna; P Eyre
Journal:  Agents Actions       Date:  1979-10

6.  The flavonoids: a brief review and study of effects on antigen-induced histamine release from human basophils.

Authors:  E Middleton; D G Krishnarao; D Atkins; G Drzewiecki
Journal:  Trans Am Clin Climatol Assoc       Date:  1981

7.  Quercetin interacts with calmodulin, a calcium regulatory protein.

Authors:  H Nishino; E Naitoh; A Iwashima; K Umezawa
Journal:  Experientia       Date:  1984-02-15

8.  Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids.

Authors:  I Mucsi; B M Prágai
Journal:  Experientia       Date:  1985-07-15

9.  A flavanone and two phenolic acids from Chrysanthemum morifolium with phytotoxic and insect growth regulating activity.

Authors:  Clifford W Beninger; Mamdouh M Abou-Zaid; Adrienne L Kistner; Rebecca H Hallett; Muhammad J Iqbal; Bernard Grodzinski; J Christopher Hall
Journal:  J Chem Ecol       Date:  2004-03       Impact factor: 2.626

10.  Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: structure-activity relationships.

Authors:  A Beretz; J P Cazenave; R Anton
Journal:  Agents Actions       Date:  1982-07
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