Literature DB >> 21228799

Fueling the fire in acute kidney injury: endothelial cells collect their Toll.

Timothy A Sutton1, Pierre C Dagher.   

Abstract

Chen et al. demonstrate endothelial expression of Toll-like receptor 4 (TLR4) in the outer medulla of the kidney early in the course of ischemic acute kidney injury. Furthermore, they provide data that support the hypothesis that activation of endothelial TLR4 in the early extension phase of AKI by damage-associated molecular pattern molecules released from injured tubules results in endothelial activation. This activation can serve to amplify inflammation and tubular damage.

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Year:  2011        PMID： 21228799      PMCID： PMC3086207          DOI： 10.1038/ki.2010.456

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  10 in total

1.  Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs.

Authors:  Graciela Andonegui; Claudine S Bonder; Francis Green; Sarah C Mullaly; Lori Zbytnuik; Eko Raharjo; Paul Kubes
Journal:  J Clin Invest       Date:  2003-04       Impact factor: 14.808

2.  Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury.

Authors:  Jianlin Chen; Reji John; James A Richardson; John M Shelton; Xin J Zhou; Yanxia Wang; Qing Qing Wu; John R Hartono; Pamela D Winterberg; Christopher Y Lu
Journal:  Kidney Int       Date:  2010-10-06       Impact factor: 10.612

Review 3.  Renal Toll-like receptors: recent advances and implications for disease.

Authors:  Tarek M El-Achkar; Pierre C Dagher
Journal:  Nat Clin Pract Nephrol       Date:  2006-10

4.  Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney.

Authors:  Tarek M El-Achkar; Xiaoping Huang; Zoya Plotkin; Ruben M Sandoval; Georges J Rhodes; Pierre C Dagher
Journal:  Am J Physiol Renal Physiol       Date:  2005-12-06

5.  Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins.

Authors:  Susu M Zughaier; Shanta M Zimmer; Anup Datta; Russell W Carlson; David S Stephens
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

Review 6.  Microvascular endothelial injury and dysfunction during ischemic acute renal failure.

Authors:  Timothy A Sutton; Charles J Fisher; Bruce A Molitoris
Journal:  Kidney Int       Date:  2002-11       Impact factor: 10.612

Review 7.  The innate immune response in ischemic acute kidney injury.

Authors:  Hye Ryoun Jang; Hamid Rabb
Journal:  Clin Immunol       Date:  2008-10-14       Impact factor: 3.969

8.  Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation.

Authors:  Hong Zhou; Graciela Andonegui; Connie H Y Wong; Paul Kubes
Journal:  J Immunol       Date:  2009-09-28       Impact factor: 5.422

9.  TLR4 activation mediates kidney ischemia/reperfusion injury.

Authors:  Huiling Wu; Gang Chen; Kate R Wyburn; Jianlin Yin; Patrick Bertolino; Josette M Eris; Stephen I Alexander; Alexandra F Sharland; Steven J Chadban
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808

10.  Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury.

Authors:  Wilco P Pulskens; Gwendoline J Teske; Loes M Butter; Joris J Roelofs; Tom van der Poll; Sandrine Florquin; Jaklien C Leemans
Journal:  PLoS One       Date:  2008-10-31       Impact factor: 3.240
  10 in total
  1 in total

1.  Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages.

Authors:  Liang Chen; Sixing Yang; Elizabeth E Zumbrun; Hongbing Guan; Prakash S Nagarkatti; Mitzi Nagarkatti
Journal:  Mol Nutr Food Res       Date:  2015-03-18       Impact factor: 5.914
  1 in total

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