| Literature DB >> 21228143 |
Stephen Valas1, Alain Le Ven, Benoit Croise, Maud Maquigneau, Cécile Perrin.
Abstract
The effects of the recent vaccinations against bluetongue virus serotype 1 (BTV-1) and BTV-8 in Europe on the reliability of enzyme-linked immunosorbent assays (ELISAs) currently used for diagnosis of small-ruminant lentivirus (SRLV) infection were examined. Primary vaccination against BTV-8 in goats induced an increase in reactivity that did not exceed 3 months in a whole-virus indirect ELISA and a competitive ELISA based on the gp135 glycoprotein. Subsequent BTV-1/8 vaccination extended the time scale of false-positive reactivity for up to 6 months. These results are of relevance for SRLV-monitoring programs.Entities:
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Year: 2011 PMID: 21228143 PMCID: PMC3067377 DOI: 10.1128/CVI.00343-10
Source DB: PubMed Journal: Clin Vaccine Immunol ISSN: 1556-679X