Jianying He1, Xiaoyuan Xu, Ann Francisco, Anthony Ferrante, Jonathan Krakoff. 1. Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA. hejianying@mail.nih.gov
Abstract
OBJECTIVE: Adipose tissue macrophages are associated with adiposity and may play a role in obesity related co-morbidities. We examined whether abdominal subcutaneous adipose tissue macrophage content (ATMc) was associated with fasting serum total cholesterol (TC), high density lipoprotein (HDL-C) and triglycerides (TG) concentrations. METHODS: 52 (35 male) of Pima Indians without diabetes participated in the study. ATMc was assessed by histochemistry (CD68+ cells) (Mphi) and gene expression of macrophage-specific markers including CD68, CSF1r, CD11b and CD11c. RESULTS: HDL-C was negatively associated with CD68, CSF1R, CD11b and CD11c expression (r=-0.31, p=0.02; r=-0.38, p<0.01; r=-0.40, p<0.01; r=-0.26, p=0.04, respectively). After adjustment for age, sex and BMI, the associations between HDL-C and CSF1R, CD11b were still significant (r=-0.31, p=0.01 and r=-0.3, p=0.02), but borderline for CD68 (r=-0.24, p=0.06). CONCLUSIONS: ATMc is associated with lower HDL-C independent of BMI indicating a link between ATMc and cardiovascular risk factors. Published by Elsevier Ireland Ltd.
OBJECTIVE: Adipose tissue macrophages are associated with adiposity and may play a role in obesity related co-morbidities. We examined whether abdominal subcutaneous adipose tissue macrophage content (ATMc) was associated with fasting serum total cholesterol (TC), high density lipoprotein (HDL-C) and triglycerides (TG) concentrations. METHODS: 52 (35 male) of Pima Indians without diabetes participated in the study. ATMc was assessed by histochemistry (CD68+ cells) (Mphi) and gene expression of macrophage-specific markers including CD68, CSF1r, CD11b and CD11c. RESULTS: HDL-C was negatively associated with CD68, CSF1R, CD11b and CD11c expression (r=-0.31, p=0.02; r=-0.38, p<0.01; r=-0.40, p<0.01; r=-0.26, p=0.04, respectively). After adjustment for age, sex and BMI, the associations between HDL-C and CSF1R, CD11b were still significant (r=-0.31, p=0.01 and r=-0.3, p=0.02), but borderline for CD68 (r=-0.24, p=0.06). CONCLUSIONS: ATMc is associated with lower HDL-C independent of BMI indicating a link between ATMc and cardiovascular risk factors. Published by Elsevier Ireland Ltd.
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