Literature DB >> 21226760

Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder.

Ronald S Swerdloff1, YanHe Lue, Peter Y Liu, Krista Erkkilä, Christina Wang.   

Abstract

UNLABELLED: 41XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene-dosage effect from genes that escape X inactivation in mouse.
CONCLUSION: The 41XXY mouse is an excellent model for KS.
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

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Year:  2011        PMID： 21226760     DOI： 10.1111/j.1651-2227.2011.02149.x

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  7 in total

1.  Feminized behavior and brain gene expression in a novel mouse model of Klinefelter Syndrome.

Authors:  Tuck C Ngun; Negar M Ghahramani; Michelle M Creek; Shayna M Williams-Burris; Hayk Barseghyan; Yuichiro Itoh; Francisco J Sánchez; Rebecca McClusky; Janet S Sinsheimer; Arthur P Arnold; Eric Vilain
Journal:  Arch Sex Behav       Date:  2014-06-13

2.  Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies.

Authors:  Armin Raznahan; YanHe Lue; Frank Probst; Deanna Greenstein; Jay Giedd; Christina Wang; Jason Lerch; Ronald Swerdloff
Journal:  Brain Struct Funct       Date:  2014-08-22       Impact factor: 3.270

Review 3.  The importance of having two X chromosomes.

Authors:  Arthur P Arnold; Karen Reue; Mansoureh Eghbali; Eric Vilain; Xuqi Chen; Negar Ghahramani; Yuichiro Itoh; Jingyuan Li; Jenny C Link; Tuck Ngun; Shayna M Williams-Burris
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-02-01       Impact factor: 6.237

4.  Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia.

Authors:  Madhuvanthi Ramaiah; Kun Tan; Terra-Dawn M Plank; Hye-Won Song; Jennifer N Chousal; Samantha Jones; Eleen Y Shum; Steven D Sheridan; Kevin J Peterson; Jörg Gromoll; Stephen J Haggarty; Heidi Cook-Andersen; Miles F Wilkinson
Journal:  EMBO Rep       Date:  2019-12-06       Impact factor: 9.071

5.  Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.

Authors:  Chao Liu; Hongbin Liu; Haobo Zhang; Lina Wang; Mengjing Li; Feifei Cai; Xiuge Wang; Li Wang; Ruidan Zhang; Sijie Yang; Wenwen Liu; Yu Liang; Liying Wang; Xiaohui Song; Shizhen Su; Hui Gao; Jing Jiang; Jinsong Li; Mengcheng Luo; Fei Gao; Qi Chen; Wei Li; Zi-Jiang Chen
Journal:  EMBO J       Date:  2021-05-12       Impact factor: 14.012

Review 6.  X-chromosome regulation and sex differences in brain anatomy.

Authors:  Armin Raznahan; Christine M Disteche
Journal:  Neurosci Biobehav Rev       Date:  2020-11-07       Impact factor: 8.989

7.  The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance.

Authors:  Xuqi Chen; Shayna M Williams-Burris; Rebecca McClusky; Tuck C Ngun; Negar Ghahramani; Hayk Barseghyan; Karen Reue; Eric Vilain; Arthur P Arnold
Journal:  Biol Sex Differ       Date:  2013-08-08       Impact factor: 5.027
  7 in total

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