Literature DB >> 2122645

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-like compounds on mitochondrial respiration.

K Suzuki1, Y Mizuno, M Yoshida.   

Abstract

Effects of MPTP-like compounds on mitochondrial respiration, activity of NADH-ubiquinone oxidoreductase (complex I) and on ATP synthesis were reported. Mitochondria prepared from mouse whole brains were used. The compounds tested include tetrahydroisoquinoline (TIQ), tetrahydropapaveroline (THP), tetrahydropapaverine (THPV), and salsolinol. TIQ, THP, and THPV significantly inhibited the state 3 respiration supported by glutamate + malate, activity of complex I and ATP synthesis. Among these compounds, THPV was most potent. Toxic properties of these compounds on mitochondria were similar to MPP+. Significance of our results was discussed with respect to etiology of Parkinson's disease.

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Year:  1990        PMID： 2122645

Source DB:  PubMed          Journal:  Adv Neurol        ISSN： 0091-3952


  12 in total

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4.  Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson's Disease Toxin MPP(.).

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5.  Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism.

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6.  Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells.

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Journal:  J Toxicol       Date:  2015-08-18

7.  Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice.

Authors:  Yun Jiao; Yuchen Dou; Georgina Lockwood; Amar Pani; Richard Jay Smeyne
Journal:  J Parkinsons Dis       Date:  2015       Impact factor: 5.568

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Review 9.  1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine with unexpected mechanism of action: new vistas of therapeutic application.

Authors:  Lucyna Antkiewicz-Michaluk; Agnieszka Wąsik; Jerzy Michaluk
Journal:  Neurotox Res       Date:  2013-05-30       Impact factor: 3.911

Review 10.  Mitochondrial dysfunction in Parkinson's disease.

Authors:  Qingsong Hu; Guanghui Wang
Journal:  Transl Neurodegener       Date:  2016-07-22       Impact factor: 8.014
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